Trial reportStrahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]2014
Diffusion tensor imaging for target volume definition in glioblastoma multiforme.
Trial report in Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Functional brain imaging interventions for radiation therapy planning in patients with glioblastoma: a systematic review.Radiation oncology (London, England) · 2022Pooled it
- White matter pathlength maps from diffusion-weighted MRI tractography for radiotherapy target planning in glioblastoma.Journal of neuro-oncology · 2026Article
- Novel radiotherapy target definition using AI-driven predictions of glioblastoma recurrence from metabolic and diffusion MRI.NPJ digital medicine · 2025Article
- DTI fiber-tracking parameters adjacent to gliomas: the role of tract irregularity value in operative planning, resection, and outcome.Journal of neuro-oncology · 2025Observational
- The role and potential of using quantitative MRI biomarkers for imaging guidance in brain cancer radiotherapy treatment planning: A systematic review.Physics and imaging in radiation oncology · 2023Review
- Diffusion tensor imaging tractography in the one-humped camel (Frontiers in veterinary science · 2023Article
- The potential of advanced MR techniques for precision radiotherapy of glioblastoma.Magma (New York, N.Y.) · 2022Review
- Conventional and advanced imaging throughout the cycle of care of gliomas.Neurosurgical review · 2021Review
- Review
- Role of MRI-Based Functional Imaging in Improving the Therapeutic Index of Radiotherapy in Cancer Treatment.Frontiers in oncology · 2021Review
- Medical Imaging Biomarker Discovery and Integration Towards AI-Based Personalized Radiotherapy.Frontiers in oncology · 2021Review
- Quantitative evaluation of diffusion tensor imaging for clinical management of glioma.Neurosurgical review · 2020Review
- On PTV definition for glioblastoma based on fiber tracking of diffusion tensor imaging data.PloS one · 2020Article
- Diffusion Tensor Imaging Tractography of White Matter Tracts in the Equine Brain.Frontiers in veterinary science · 2020Article
- An Open-Source Tool for Anisotropic Radiation Therapy Planning in Neuro-oncology Using DW-MRI Tractography.Frontiers in oncology · 2019Article
- Molecular and Clinical Insights into the Invasive Capacity of Glioblastoma Cells.Journal of oncology · 2019Review
- Predicting patterns of failure in temporal lobe GBMs: possible implications on radiotherapy treatment portals.Radiation oncology (London, England) · 2018Article
- A fuzzy feature fusion method for auto-segmentation of gliomas with multi-modality diffusion and perfusion magnetic resonance images in radiotherapy.Scientific reports · 2018Article
- Advances in Radiotherapy for Glioblastoma.Frontiers in neurology · 2017Review
- Diffusion and perfusion weighted magnetic resonance imaging for tumor volume definition in radiotherapy of brain tumors.Radiation oncology (London, England) · 2016Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionDiffusion tensor imaging (DTI) is an MR-based technique that may better detect the peritumoural region than MRI. Our aim was to explore the feasibility of using DTI for target volume delineation in glioblastoma patients. MATERIALS AND
methodsMR tensor tracts and maps of the isotropic (p) and anisotropic (q) components of water diffusion were coregistered with CT in 13 glioblastoma patients. An in-house image processing program was used to analyse water diffusion in each voxel of interest in the region of the tumour. Tumour infiltration was mapped according to validated criteria and contralateral normal brain was used as an internal control. A clinical target volume (CTV) was generated based on the T1-weighted image obtained using contrast agent (T1Gd), tractography and the infiltration map. This was compared to a conventional T2-weighted CTV (T2-w CTV).
resultsDefinition of a diffusion-based CTV that included the adjacent white matter tracts proved highly feasible. A statistically significant difference was detected between the DTI-CTV and T2-w CTV volumes (p < 0.005, t = 3.480). As the DTI-CTVs were smaller than the T2-w CTVs (tumour plus peritumoural oedema), the pq maps were not simply detecting oedema. Compared to the clinical planning target volume (PTV), the DTI-PTV showed a trend towards volume reduction. These diffusion-based volumes were smaller than conventional volumes, yet still included sites of tumour recurrence.
conclusionExtending the CTV along the abnormal tensor tracts in order to preserve coverage of the likely routes of dissemination, whilst sparing uninvolved brain, is a rational approach to individualising radiotherapy planning for glioblastoma patients.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.