ArticleNanomedicine (London, England)2014
Assessing the impact of engineered nanoparticles on wound healing using a novel in vitro bioassay.
Article in Nanomedicine (London, England), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed.
- Effect and Mechanism of PINK1/Parkin-Mediated Mitochondrial Autophagy in Rat Lung Injury Induced by Nano Lanthanum Oxide.Nanomaterials (Basel, Switzerland) · 2022Article
- Metallic Engineered Nanomaterials and Ocular Toxicity: A Current Perspective.Pharmaceutics · 2022Review
- Metal Oxide Engineered Nanomaterials Modulate Rabbit Corneal Fibroblast to Myofibroblast Transformation.Translational vision science & technology · 2021Article
- Transcorneal delivery of topically applied silver nanoparticles does not delay epithelial wound healing.NanoImpact · 2021Article
- Effects of ambient particulate matter on a reconstructed human corneal epithelium model.Scientific reports · 2021Article
- Article
- Nanoparticle exposures from nano-enabled toner-based printing equipment and human health: state of science and future research needs.Critical reviews in toxicology · 2017Review
- Preparation, characterization, and in vitro dosimetry of dispersed, engineered nanomaterials.Nature protocols · 2017Article
- Article
- Eye irritation testing of nanomaterials using the EpiOcular™ eye irritation test and the bovine corneal opacity and permeability assay.Particle and fibre toxicology · 2016Article
- Toxicological Assessment of CoO and La2O3 Metal Oxide Nanoparticles in Human Small Airway Epithelial Cells.Toxicological sciences : an official journal of the Society of Toxicology · 2016Article
- Article
- Biomaterials and Nanotherapeutics for Enhancing Skin Wound Healing.Frontiers in bioengineering and biotechnology · 2016Review
- In vivo epigenetic effects induced by engineered nanomaterials: A case study of copper oxide and laser printer-emitted engineered nanoparticles.Nanotoxicology · 2016Article
- Progress in corneal wound healing.Progress in retinal and eye research · 2015Review
- Zinc oxide nanoparticles inhibit murine photoreceptor-derived cell proliferation and migration via reducing TGF-β and MMP-9 expression in vitro.Cell proliferation · 2015Article
- Implications of in vitro dosimetry on toxicological ranking of low aspect ratio engineered nanomaterials.Nanotoxicology · 2015Article
- Consumer exposures to laser printer-emitted engineered nanoparticles: A case study of life-cycle implications from nano-enabled products.Nanotoxicology · 2015Article
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
aimAs engineered nanoparticles (ENPs) increasingly enter consumer products, humans become increasingly exposed. The first line of defense against ENPs is the epithelium, the integrity of which can be compromised by wounds induced by trauma, infection, or surgery, but the implications of ENPs on wound healing are poorly understood. MATERIALS &
methodsHerein, we developed an in vitro assay to assess the impact of ENPs on the wound healing of cells from human cornea. RESULTS & DISCUSSION: We show that industrially relevant ENPs impeded wound healing and cellular migration in a manner dependent on the composition, dose and size of the ENPs as well as cell type. CuO and ZnO ENPs impeded both viability and wound healing for both fibroblasts and epithelial cells. Carboxylated polystyrene ENPs retarded wound healing of corneal fibroblasts without affecting viability.
conclusionOur results highlight the impact of ENPs on cellular wound healing and provide useful tools for studying the physiological impact of ENPs.
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