Evidence map›Paper›PMID 24823351›Full record

ReviewRNA biology2014

Versatile microRNA biogenesis in animals and their viruses.

Mingyi Xie, Joan A Steitz

Open access · bronzeAbstract readReview
In one paragraph

Review in RNA biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 57 citations in OpenAlex.

  1. Article
  2. Review
  3. The Role of Cystathionine-β-Synthase, HJournal of molecular neuroscience : MN · 2023
    Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Ebola Virus Encodes Two microRNAs in Huh7-Infected Cells.International journal of molecular sciences · 2022
    Article
  9. Review
  10. Review
  11. Review
  12. Article
  13. Article
  14. Anti-Hepatocellular Carcinoma Biomolecules: Molecular Targets Insights.International journal of molecular sciences · 2021
    Review
  15. Article
  16. Review
  17. Review
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Mingyi XieHoward Hughes Medical Institute; Yale University; Department of Molecular Biophysics and Biochemistry; New Haven, CT USA.
Joan A SteitzHoward Hughes Medical Institute; Yale University; Department of Molecular Biophysics and Biochemistry; New Haven, CT USA.
Yale University · US

Funding

VIRAL SMALL RNPS--ROLES IN CELL TRANSFORMATIONP01CA016038 · NCI · YALE UNIVERSITY · PI DIMAIO, DANIEL C. · 1985 to 2020
$25.6M
Vertebrate Non-Coding RNPs: Integrating function, biogenesis and survivalR01GM026154 · NIGMS · YALE UNIVERSITY · PI STEITZ, JOAN A. · 1985 to 2014
$4.0M
AUTOANTIBODY PROBES FOR MAMMALIAN GENE EXPRESSIONR37GM026154 · NIGMS · YALE UNIVERSITY · PI STEITZ, JOAN A. · 1989 to 1998
–
Howard Hughes Medical InstituteNCI NIH HHS CA16038NCI NIH HHS P01 CA016038NIGMS NIH HHS GM026154NIGMS NIH HHS R01 GM026154
6 · The paper itself

Abstract

MicroRNAs (miRNAs) are ubiquitous gene regulators that modulate essential cellular processes at the post-transcriptional level. In metazoans and their viruses, most miRNAs are produced from hairpin-containing primary transcripts that are sequentially cleaved by nuclear Drosha and cytoplasmic Dicer. In the last decade, alternative mechanisms that bypass either the Drosha or Dicer cleavage step have emerged, increasing the complexity of the miRNA regulatory network. Here, we highlight non-canonical pathways that generate miRNAs using a variety of molecular machineries that play fundamental roles in the biogenesis and processing of other classes of cellular RNAs.

Indexed as

RNA Processing, Post-TranscriptionalTranscription, GeneticAnimalsMicroRNAsRibonuclease IIIRNA CapsRNA PrecursorsVirusesMicroRNAsRibonuclease IIIRNA CapsRNA PrecursorsAGO2 slicer activityDicerexportin-5Integratorm7G-capped pre-miRNAMicroprocessormicroRNA biogenesismirtrontRNaseZviral microRNA

Identifiers

PMID24823351
PMCPMC4156499
OpenAlexW1984202454

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.