ArticleBioMed research international2014
Melatonin in the regulation of liver steatosis following prenatal glucocorticoid exposure.
Article in BioMed research international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Epigenetic effects of endogenous and exogenous glucocorticosteroids during pregnancy on the offspring: a systematic-narrative review.Hormones (Athens, Greece) · 2025Pooled it
- The Effects of Melatonin on Elevated Liver Enzymes during Statin Treatment.BioMed research international · 2017Trial
- Prenatal melatonin reprograms liver injury in male pups caused by maternal exposure to a high-fat diet and microplastics.Apoptosis : an international journal on programmed cell death · 2025Article
- Breastfeeding and Future Cardiovascular, Kidney, and Metabolic Health-A Narrative Review.Nutrients · 2025Review
- Exploring Oxidative Stress and Metabolic Dysregulation in Lung Tissues of Offspring Rats Exposed to Prenatal Polystyrene Microplastics: Effects of Melatonin Treatment.Antioxidants (Basel, Switzerland) · 2024Article
- Nutritional Approaches Targeting Gut Microbiota in Oxidative-Stress-Associated Metabolic Syndrome: Focus on Early Life Programming.Nutrients · 2024Review
- Melatonin Use during Pregnancy and Lactation Complicated by Oxidative Stress: Focus on Offspring's Cardiovascular-Kidney-Metabolic Health in Animal Models.Antioxidants (Basel, Switzerland) · 2024Review
- Prenatal High-Fat Diet Combined with Microplastic Exposure Induces Liver Injury via Oxidative Stress in Male Pups.International journal of molecular sciences · 2023Article
- Maternal hepatic immunology during pregnancy.Frontiers in immunology · 2023Review
- Metabolic Syndrome Programming and Reprogramming: Mechanistic Aspects of Oxidative Stress.Antioxidants (Basel, Switzerland) · 2022Review
- Prophylactic administration of carnosine and melatonin abates the incidence of apoptosis, inflammation, and DNA damage induced by titanium dioxide nanoparticles in rat livers.Environmental science and pollution research international · 2020Article
- Expression of melatonin receptors and CD4 in the ovine thymus, lymph node, spleen and liver during early pregnancy.Immunology · 2020Article
- Light and Circadian Signaling Pathway in Pregnancy: Programming of Adult Health and Disease.International journal of molecular sciences · 2020Review
- Protective role of melatonin in early-stage and end-stage liver cirrhosis.Journal of cellular and molecular medicine · 2019Review
- Maternal exposure to environmentally relevant doses of bisphenol A causes reproductive dysfunction in F1 adult male rats: protective role of melatonin.Environmental science and pollution research international · 2019Article
- Regulation of Leptin Methylation Not via Apoptosis by Melatonin in the Rescue of Chronic Programming Liver Steatosis.International journal of molecular sciences · 2018Article
- Melatonin alleviates liver steatosis induced by prenatal dexamethasone exposure and postnatal high-fat diet.Experimental and therapeutic medicine · 2018Article
- Prenatal dexamethasone and postnatal high-fat diet have a synergistic effect of elevating blood pressure through a distinct programming mechanism of systemic and adipose renin-angiotensin systems.Lipids in health and disease · 2018Article
- Effects of Melatonin on Liver Injuries and Diseases.International journal of molecular sciences · 2017Review
- Developmental Programming of Adult Disease: Reprogramming by Melatonin?International journal of molecular sciences · 2017Review
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nonalcoholic fatty liver disease patients are characterized by hepatic steatosis. Prenatal glucocorticoid overexposure can result in steatosis. In this study, we aimed to determine the mechanism and cellular apoptosis of prenatal glucocorticoid overexposure in rats and whether melatonin can rescue the prenatal glucocorticoid-induced steatosis and apoptosis in neonatal rats. Pregnant Sprague-Dawley rats at gestational days 14 to 21 were administered dexamethasone. Acute effects of prenatal programming liver were assessed at postnatal day 7. The expression of proteins involved in the apoptotic and methylation pathways was analyzed by RT-PCR and Western blotting. Apoptosis and steatosis were examined by histology staining. The liver steatosis and apoptosis were increased in prenatal glucocorticoid group more than in control group and decreased in melatonin group. The expression of leptin decreased in prenatal glucocorticoid and increased in melatonin group by liver RT-PCR and Western blot study. Caspase 3, TNF- α proteins expression, and TUNEL stains increased in prenatal glucocorticoid compared with control and decreased in melatonin group. The liver histone deacetylase, DNA methyltransferase activity, and DNA methylation were increased in prenatal glucocorticoid and decreased in melatonin group. The present study showed that the prenatal glucocorticoid induced programming liver steatosis at day 7 after delivery, possibly via altered leptin expression. Melatonin can reverse the methylation of leptin and decreased liver steatosis.
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