ReviewBioMed research international2014
Immune responses in Parkinson's disease: interplay between central and peripheral immune systems.
Review in BioMed research international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed, 89 citations in OpenAlex.
- Network-Based Analysis for the Quantification of Brain and Body Immune Axes with Total-Body PET Imaging.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026Article
- Role of CXCR3 and CXCR6 on Circulating T Cells in Patients With Parkinson's Disease.Scandinavian journal of immunology · 2026Article
- Exercise training upregulates CD55 to suppress complement-mediated synaptic phagocytosis in Parkinson's disease.Journal of neuroinflammation · 2024Article
- The Roles of Exosomal Proteins: Classification, Function, and Applications.International journal of molecular sciences · 2023Review
- Peripheral inflammatory immune response differs among sporadic and familial Parkinson's disease.NPJ Parkinson's disease · 2023Article
- Characterization of Lipopolysaccharide Effects on LRRK2 Signaling in RAW Macrophages.International journal of molecular sciences · 2023Article
- Dysfunction of the noradrenergic system drives inflammation, α-synucleinopathy, and neuronal loss in mouse colon.Frontiers in immunology · 2023Article
- Three Pairs of Novel Enantiomeric 8-International journal of molecular sciences · 2022Article
- Targeting NMDA Receptors at the Neurovascular Unit: Past and Future Treatments for Central Nervous System Diseases.International journal of molecular sciences · 2022Review
- Parkinson's Disease Subtyping Using Clinical Features and Biomarkers: Literature Review and Preliminary Study of Subtype Clustering.Diagnostics (Basel, Switzerland) · 2022Review
- Identification of hub genes of Parkinson's disease through bioinformatics analysis.Frontiers in neuroscience · 2022Article
- The Potential Role of COVID-19 in the Pathogenesis of Multiple Sclerosis-A Preliminary Report.Viruses · 2021Review
- Systemic oxidative stress and cognitive function in Parkinson's disease with different PWMH or DWMH lesions.BMC neurology · 2021Article
- Immune Response in Neurological Pathology: Emerging Role of Central and Peripheral Immune Crosstalk.Frontiers in immunology · 2021Review
- Alpha-Lipoic Acid Protects Co-Exposure to Lead and Zinc Oxide Nanoparticles Induced Neuro, Immuno and Male Reproductive Toxicity in Rats.Frontiers in pharmacology · 2021Article
- Neuroinflammation: An Integrating Overview of Reactive-Neuroimmune Cell Interactions in Health and Disease.Mediators of inflammation · 2021Review
- Lipoprotein-Associated Phospholipase A2 Is a Risk Factor for Patients With Parkinson's Disease.Frontiers in neuroscience · 2021Article
- Peripheral innate immune and bacterial signals relate to clinical heterogeneity in Parkinson's disease.Brain, behavior, and immunity · 2020Article
- Cerebrospinal Fluid Cytokines and Neurodegeneration-Associated Proteins in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2020Article
- Propolis as A Potential Disease-Modifying Strategy in Parkinson's Disease: Cardioprotective and Neuroprotective Effects in the 6-OHDA Rat Model.Nutrients · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The etiology of Parkinson's disease (PD) is complex and most likely involves numerous environmental and heritable risk factors. Recent studies establish that central and peripheral inflammation occurs in the prodromal stage of the disease and sustains disease progression. Aging, heritable risk factors, or environmental exposures may contribute to the initiation of central or peripheral inflammation. One emerging hypothesis is that inflammation plays a critical role in PD neuropathology. Increasing evidence suggest that activation of the peripheral immune system exacerbates the discordant central inflammatory response and synergistically drives neurodegeneration. We provide an overview of current knowledge on the temporal profile of central and peripheral immune responses in PD and discuss the potential synergistic effects of the central and peripheral inflammation in disease development. The understanding of the nature of the chronic inflammation in disease progression and the possible risk factors that contribute to altered central and peripheral immune responses will offer mechanistic insights into PD etiology and pathology and benefit the development of effective tailored therapeutics for human PD.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.