Evidence map›Paper›PMID 24822065›Full record

ArticleInternational journal of endocrinology2014

Vitamin D Binding Protein Affects the Correlation of 25(OH)D and Frailty in the Older Men.

Yi Wang, Yan-Jiao Wang, Jun-Kun Zhan, Zhi-Yong Tang, Wu Huang, Pan Tan, Shan Gao, Cai-Li Ma, Zai-Jin Jian, You-Shuo Liu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of endocrinology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 2 pooled it
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Pinpointing a Role for Vitamin D in Frailty: A Time for Animal Models?Advances in geriatric medicine and research · 2021
    Article
  6. Can Serum Nitrosoproteome Predict Longevity of Aged Women?International journal of molecular sciences · 2020
    Article
  7. Article
  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Yi WangGeriatric Department of the Second Xiang-Ya Hospital, Institute of Aging and Geriatric, Central South University, Changsha, Hunan 410011, China.
Yan-Jiao WangGeriatric Department of the Second Xiang-Ya Hospital, Institute of Aging and Geriatric, Central South University, Changsha, Hunan 410011, China.
Jun-Kun ZhanGeriatric Department of the Second Xiang-Ya Hospital, Institute of Aging and Geriatric, Central South University, Changsha, Hunan 410011, China.
Zhi-Yong TangGeriatric Department of the Second Xiang-Ya Hospital, Institute of Aging and Geriatric, Central South University, Changsha, Hunan 410011, China.
Wu HuangGeriatric Department of the Second Xiang-Ya Hospital, Institute of Aging and Geriatric, Central South University, Changsha, Hunan 410011, China.
Pan TanGeriatric Department of the Second Xiang-Ya Hospital, Institute of Aging and Geriatric, Central South University, Changsha, Hunan 410011, China.
Shan GaoGeriatric Department of the Second Xiang-Ya Hospital, Institute of Aging and Geriatric, Central South University, Changsha, Hunan 410011, China.
Cai-Li MaGeriatric Department of the Second Xiang-Ya Hospital, Institute of Aging and Geriatric, Central South University, Changsha, Hunan 410011, China.
Zai-Jin JianGeriatric Department of the Second Xiang-Ya Hospital, Institute of Aging and Geriatric, Central South University, Changsha, Hunan 410011, China.
You-Shuo LiuGeriatric Department of the Second Xiang-Ya Hospital, Institute of Aging and Geriatric, Central South University, Changsha, Hunan 410011, China.
Central South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vitamin D binding protein (DBP) may alter the biologic activity of 25-hydroxyvitamin D [25(OH)D]. The objective of our present study was to determine the joint effect of serum 25(OH)D and DBP on the risk of frailty. Five hundred sixteen male participants aged 70 years or older were recruited in Changsha city and its surrounding area in Hunan province of China. Frailty was defined as the presence of at least three of the five following criteria: weakness, low physical activity, slow walking speed, exhaustion, and weight loss. Multivariate linear regression analysis was performed to assess the relationship between 25(OH)D and DBP levels. Odds ratios (ORs) for frailty were evaluated across quartiles of 25(OH)D and DBP levels, adjusted age, education, and body mass index. The results showed that participants in the lowest quartile of 25(OH)D and the highest quartile of DBP levels, the lowest quartile of 25(OH)D and the lowest quartile of DBP levels, and those in the the lower quartile of 25(OH)D and lowest quartile of DBP levels had significantly higher OR of being frail compared with those in the highest quartile of 25(OH)D and lowest quartile of DBP, with OR of 3.18 (95% CI: 1.46-4.56, P < 0.05), 2.63 (95% CI: 1.31-3.68, P < 0.01), and 2.52 (95% CI: 1.22-3.52, P < 0.05), respectively. The results indicate that the joint effect of serum 25(OH)D and DBP levels is associated with the risk of frailty, and serum DBP levels affects 25(OH)D-frailty relationship in the older men.

Identifiers

PMID24822065
PMCPMC4005149
OpenAlexW2094418554

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.