Evidence map›Paper›PMID 24822055›Full record

ReviewFrontiers in genetics2014

Losing the stem-loop structure from metazoan mitochondrial tRNAs and co-evolution of interacting factors.

Yoh-Ichi Watanabe, Takuma Suematsu, Takashi Ohtsuki

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers.

0numbers the graph read from it
0cells of the map it votes in
88citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

88 citing papers in PubMed, 142 citations in OpenAlex.

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  6. Comparative Mitogenomics ofAnimals : an open access journal from MDPI · 2026
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  11. Complete Mitochondrial Genomes ofAnimals : an open access journal from MDPI · 2025
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  19. The Complete Mitochondrial Genome ofEcology and evolution · 2025
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  20. Article

28 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Yoh-Ichi WatanabeDepartment of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo Tokyo, Japan.
Takuma SuematsuDepartment of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo Tokyo, Japan.
Takashi OhtsukiDepartment of Biotechnology, Okayama University Okayama, Japan.
The University of Tokyo · JPOkayama University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Conventional tRNAs have highly conserved sequences, four-armed cloverleaf secondary structures, and L-shaped tertiary structures. However, metazoan mitochondrial tRNAs contain several exceptional structures. Almost all tRNAs(Ser) for AGY/N codons lack the D-arm. Furthermore, in some nematodes, no four-armed cloverleaf-type tRNAs are present: two tRNAs(Ser) without the D-arm and 20 tRNAs without the T-arm are found. Previously, we showed that in nematode mitochondria, an extra elongation factor Tu (EF-Tu) has evolved to support interaction with tRNAs lacking the T-arm, which interact with C-terminal domain 3 in conventional EF-Tu. Recent mitochondrial genome analyses have suggested that in metazoan lineages other than nematodes, tRNAs without the T-arm are present. Furthermore, even more simplified tRNAs are predicted in some lineages. In this review, we discuss mitochondrial tRNAs with divergent structures, as well as protein factors, including EF-Tu, that support the function of truncated metazoan mitochondrial tRNAs.

Indexed as

aminoacyl-tRNA synthetaseD-armelongation factor Tumitochondrial tRNAribosomeT-armtRNA nucleotidyltransferase

Identifiers

PMID24822055
PMCPMC4013460
OpenAlexW2141187709

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.