ArticleFrontiers in neural circuits2014
Coincidence detection in the medial superior olive: mechanistic implications of an analysis of input spiking patterns.
Article in Frontiers in neural circuits, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 42 citations in OpenAlex.
- Network hypermotifs in biological systems: structure, dynamics, and functional implications.NPJ systems biology and applications · 2026Review
- Continuous Vibration-Driven Virtual Tactile Motion Perception Across Fingertips.Sensors (Basel, Switzerland) · 2025Article
- Somatic Integration of Incoherent Dendritic Inputs in the Gerbil Medial Superior Olive.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Glycinergic axonal inhibition subserves acute spatial sensitivity to sudden increases in sound intensity.eLife · 2021Article
- Arrangement of Excitatory Synaptic Inputs on Dendrites of the Medial Superior Olive.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Structural Refinement of the Auditory Brainstem Neurons in Baboons During Perinatal Development.Frontiers in cellular neuroscience · 2021Article
- Neuronal population model of globular bushy cells covering unit-to-unit variability.PLoS computational biology · 2019Article
- Cortical mechanisms of spatial hearing.Nature reviews. Neuroscience · 2019Review
- Improved Neural Coding of ITD with Bilateral Cochlear Implants by Introducing Short Inter-pulse Intervals.Journal of the Association for Research in Otolaryngology : JARO · 2018Article
- Across Species "Natural Ablation" Reveals the Brainstem Source of a Noninvasive Biomarker of Binaural Hearing.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Physiological models of the lateral superior olive.PLoS computational biology · 2017Article
- Input timing for spatial processing is precisely tuned via constant synaptic delays and myelination patterns in the auditory brainstem.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Article
- Sensitivity to Interaural Time Differences Conveyed in the Stimulus Envelope: Estimating Inputs of Binaural Neurons Through the Temporal Analysis of Spike Trains.Journal of the Association for Research in Otolaryngology : JARO · 2016Article
- Roles for Coincidence Detection in Coding Amplitude-Modulated Sounds.PLoS computational biology · 2016Article
- Predicting binaural responses from monaural responses in the gerbil medial superior olive.Journal of neurophysiology · 2016Article
- Auditory midbrain representation of a break in interaural correlation.Journal of neurophysiology · 2015Article
- Maps of interaural delay in the owl's nucleus laminaris.Journal of neurophysiology · 2015Article
- In vivo coincidence detection in mammalian sound localization generates phase delays.Nature neuroscience · 2015Article
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3 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Coincidence detection by binaural neurons in the medial superior olive underlies sensitivity to interaural time difference (ITD) and interaural correlation (ρ). It is unclear whether this process is akin to a counting of individual coinciding spikes, or rather to a correlation of membrane potential waveforms resulting from converging inputs from each side. We analyzed spike trains of axons of the cat trapezoid body (TB) and auditory nerve (AN) in a binaural coincidence scheme. ITD was studied by delaying "ipsi-" vs. "contralateral" inputs; ρ was studied by using responses to different noises. We varied the number of inputs; the monaural and binaural threshold and the coincidence window duration. We examined physiological plausibility of output "spike trains" by comparing their rate and tuning to ITD and ρ to those of binaural cells. We found that multiple inputs are required to obtain a plausible output spike rate. In contrast to previous suggestions, monaural threshold almost invariably needed to exceed binaural threshold. Elevation of the binaural threshold to values larger than 2 spikes caused a drastic decrease in rate for a short coincidence window. Longer coincidence windows allowed a lower number of inputs and higher binaural thresholds, but decreased the depth of modulation. Compared to AN fibers, TB fibers allowed higher output spike rates for a low number of inputs, but also generated more monaural coincidences. We conclude that, within the parameter space explored, the temporal patterns of monaural fibers require convergence of multiple inputs to achieve physiological binaural spike rates; that monaural coincidences have to be suppressed relative to binaural ones; and that the neuron has to be sensitive to single binaural coincidences of spikes, for a number of excitatory inputs per side of 10 or less. These findings suggest that the fundamental operation in the mammalian binaural circuit is coincidence counting of single binaural input spikes.
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