ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2014
Immune responses during spontaneous control of HIV and AIDS: what is the hope for a cure?
Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 26 citations in OpenAlex.
- HIV-Host Cell Interactions.Cells · 2023Review
- Editorial: Innate immune responses in HIV controllers.Frontiers in immunology · 2023Article
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- Atherosclerosis in HIV Patients: What Do We Know so Far?International journal of molecular sciences · 2022Review
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- Correlation of Leukocyte Subtypes, Neutrohyl Lymphocyte Ratio, and Functional Outcome in Brain Metastasis.Open access Macedonian journal of medical sciences · 2018Article
- Systemic DPP4 activity is reduced during primary HIV-1 infection and is associated with intestinal RORCJournal of the International AIDS Society · 2018Article
- Codon optimization and improved delivery/immunization regimen enhance the immune response against wild-type and drug-resistant HIV-1 reverse transcriptase, preserving its Th2-polarity.Scientific reports · 2018Article
- Antibody-Mediated Therapy against HIV/AIDS: Where Are We Standing Now?Journal of pathogens · 2018Review
- HIV-specific T-cell Responses and Generalized Activation in HIV-1 Infected Long-term Non-progressors and Progressors from South India.Current HIV research · 2018Article
- Natural killer cells migrate into and control simian immunodeficiency virus replication in lymph node follicles in African green monkeys.Nature medicine · 2017Article
- Second European Round Table on the Future Management of HIV: 10-11 October 2014, Barcelona, Spain.Journal of virus eradication · 2015Article
- Chloroquine and beyond: exploring anti-rheumatic drugs to reduce immune hyperactivation in HIV/AIDS.Retrovirology · 2015Review
- Preface. The science of infectious diseases.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2014Article
- Mathematical Models of HIV Latency.Current topics in microbiology and immunologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
HIV research has made rapid progress and led to remarkable achievements in recent decades, the most important of which are combination antiretroviral therapies (cART). However, in the absence of a vaccine, the pandemic continues, and additional strategies are needed. The 'towards an HIV cure' initiative aims to eradicate HIV or at least bring about a lasting remission of infection during which the host can control viral replication in the absence of cART. Cases of spontaneous and treatment-induced control of infection offer substantial hope. Here, we describe the scientific knowledge that is lacking, and the priorities that have been established for research into a cure. We discuss in detail the immunological lessons that can be learned by studying natural human and animal models of protection and spontaneous control of viraemia or of disease progression. In particular, we describe the insights we have gained into the immune mechanisms of virus control, the impact of early virus-host interactions and why chronic inflammation, a hallmark of HIV infection, is an obstacle to a cure. Finally, we enumerate current interventions aimed towards improving the host immune response.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.