ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2014
Heritable strategies for controlling insect vectors of disease.
Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 125 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
125 citing papers in PubMed.
- Host range ofMicrobiology spectrum · 2026Article
- Evidence for Threshold-like Dynamics inInsects · 2026Article
- Present and Future of Mosquito-Borne Disease Control in Europe with a Specific Focus on the Mediterranean.Insects · 2026Review
- Mapping Gene Drive Dynamics onto Mendelian Models.bioRxiv : the preprint server for biology · 2026Article
- Reducing Close Encounters with Insect Pests and Vectors: The Past, Present and Future of Insect Repellents.Insects · 2026Review
- Article
- Article
- Exploring the Role of Pheromones and CRISPR/Cas9 in the Behavioral and Olfactory Mechanisms ofInsects · 2025Review
- Extended time to maturity in Anopheles coluzzii: Implications of late egg hatch for vector control and transgene fitness.Medical and veterinary entomology · 2025Article
- Pyrethroid resistance in Aedes aegypti: genetic mechanisms worldwide, and recommendations for effective vector control.Parasites & vectors · 2025Review
- Understanding the genetics of sex determination in insects and its relevance to genetic pest management.Insect molecular biology · 2025Review
- ExploitingPathogens (Basel, Switzerland) · 2025Review
- Engineering drive-selection balance for localized population suppression with neutral dynamics.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- A Y chromosome-linked genome editor for efficient population suppression in the malaria vector Anopheles gambiae.Nature communications · 2025Article
- Natural variation in timing of egg hatching, response to water agitation, and bidirectional selection of early and late hatching strains of the malaria mosquito Anopheles gambiae sensu lato.Parasites & vectors · 2024Article
- Advancements and Future Prospects of CRISPR-Cas-Based Population Replacement Strategies in Insect Pest Management.Insects · 2024Review
- Introgression of a synthetic sex ratio distortion transgene into different genetic backgrounds of Anopheles coluzzii.Insect molecular biology · 2023Article
- Evaluating the Mating Competency of Genetically Modified Male Mosquitoes in Laboratory Conditions.Frontiers in tropical diseases · 2023Article
- The size of larval rearing container modulates the effects of diet amount and larval density on larval development in Aedes aegypti.PloS one · 2023Article
- Harnessing Wolbachia cytoplasmic incompatibility alleles for confined gene drive: A modeling study.PLoS genetics · 2023Article
65 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mosquito-borne diseases are causing a substantial burden of mortality, morbidity and economic loss in many parts of the world, despite current control efforts, and new complementary approaches to controlling these diseases are needed. One promising class of new interventions under development involves the heritable modification of the mosquito by insertion of novel genes into the nucleus or of Wolbachia endosymbionts into the cytoplasm. Once released into a target population, these modifications can act to reduce one or more components of the mosquito population's vectorial capacity (e.g. the number of female mosquitoes, their longevity or their ability to support development and transmission of the pathogen). Some of the modifications under development are designed to be self-limiting, in that they will tend to disappear over time in the absence of recurrent releases (and hence are similar to the sterile insect technique, SIT), whereas other modifications are designed to be self-sustaining, spreading through populations even after releases stop (and hence are similar to traditional biological control). Several successful field trials have now been performed with Aedes mosquitoes, and such trials are helping to define the appropriate developmental pathway for this new class of intervention.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.