Evidence map›Paper›PMID 24821734›Full record

ArticleJournal of the American Medical Informatics Association : JAMIA

Scalable Collaborative Infrastructure for a Learning Healthcare System (SCILHS): architecture.

Kenneth D Mandl, Isaac S Kohane, Douglas McFadden, Griffin M Weber, Marc Natter, Joshua Mandel, Sebastian Schneeweiss, Sarah Weiler, Jeffrey G Klann, Jonathan Bickel and 11 more

Registry-linked trialAbstract read
In one paragraph

Article in Journal of the American Medical Informatics Association : JAMIA. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03911687 (Communicating Narrative Concerns Entered by RNs), which is not on this map. Cited by 55 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03911687 nacompletednot on this map

Communicating Narrative Concerns Entered by RNs (CONCERN) Clinical Decision Support (CDS) System

TypeinterventionalSponsorColumbia UniversityRan2020 to 2022Enrolled60,893ConditionsHospital Acquired ConditionArmsCONCERN CDS system notification
3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Advancing a learning health system through biomedical and health informatics.Journal of the American Medical Informatics Association : JAMIA · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Progress toward a science of learning systems for healthcare.Journal of the American Medical Informatics Association : JAMIA · 2021
    Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Kenneth D MandlChildren's Hospital Informatics Program at Harvard-MIT Health Sciences and Technology, Boston, Massachusetts, USA Center for Biomedical Informatics, Harvard Medical School, Boston, Massachusetts, USA Harvard Catalyst, Harvard Medical School, Boston, Massachusetts, USA Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA.
Isaac S KohaneChildren's Hospital Informatics Program at Harvard-MIT Health Sciences and Technology, Boston, Massachusetts, USA Center for Biomedical Informatics, Harvard Medical School, Boston, Massachusetts, USA Harvard Catalyst, Harvard Medical School, Boston, Massachusetts, USA Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA.
Douglas McFaddenCenter for Biomedical Informatics, Harvard Medical School, Boston, Massachusetts, USA Harvard Catalyst, Harvard Medical School, Boston, Massachusetts, USA.
Griffin M WeberCenter for Biomedical Informatics, Harvard Medical School, Boston, Massachusetts, USA Biomedical Research Informatics Core, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Marc NatterChildren's Hospital Informatics Program at Harvard-MIT Health Sciences and Technology, Boston, Massachusetts, USA Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA.
Joshua MandelChildren's Hospital Informatics Program at Harvard-MIT Health Sciences and Technology, Boston, Massachusetts, USA Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA.
Sebastian SchneeweissDivision of Pharmacoepidemiology, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Sarah WeilerHarvard Catalyst, Harvard Medical School, Boston, Massachusetts, USA.
Jeffrey G KlannLaboratory of Computer Science, Massachusetts General Hospital, Boston, Massachusetts, USA.
Jonathan BickelChildren's Hospital Informatics Program at Harvard-MIT Health Sciences and Technology, Boston, Massachusetts, USA Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA Information Services Department, Boston Children's Hospital, Boston, Massachusetts, USA.
William G AdamsBoston University School of Medicine/Boston Medical Center, Boston, Massachusetts, USA Boston University Clinical and Translational Sciences Institute, Boston, Massachusetts, USA.
Yaorong GeCollege of Computing and Informatics, University of North Carolina at Charlotte, Charlotte, North Carolina, USA.
Xiaobo ZhouDepartment of Radiology, Center for Bioinformatics & Systems Biology, Wake Forest University Health Science, Winston-Salem, North Carolina, USA.
James PerkinsClark Atlanta University, Atlanta, Georgia, USA Research Centers in Minority Institutions Translational Research Network, Data Coordinating Center, Jackson State University, Jackson, Mississippi, USA.
Keith MarsoloCincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Elmer BernstamDivision of Biomedical Informatics, Biomedical Informatics and Department of Internal Medicine, The University of Texas Health Science Center at Houston, Houston, Texas, USA.
John ShowalterUniversity of Mississippi Medical Center, Jackson, Mississippi, USA.
Alexander QuarshieDepartment of Internal Medicine, Community Health and Preventive Medicine and Clinical Research Center, Morehouse School of Medicine, Atlanta, Georgia, USA.
Elizabeth OfiliDepartment of Internal Medicine, Clinical Research Center, Morehouse School of Medicine, Atlanta, Georgia, USA.
George HripcsakDepartment of Biomedical Informatics, Columbia University, New York,  New York, USA.
Shawn N MurphyLaboratory of Computer Science, Massachusetts General Hospital, Boston, Massachusetts, USA Partners HealthCare Systems, Information Systems, Charlestown, Massachusetts, USA.

Funding

Informatics for Integrating Biology/ the Bedside (RMI)U54LM008748 · NLM · BRIGHAM AND WOMEN'S HOSPITAL · PI KOHANE, ISAAC S. · 2004 to 2013
$39.0M
Atlanta Clinical and Translational Science Institute (ACTSI) RenewalUL1TR000454 · NCATS · EMORY UNIVERSITY · PI STEPHENS, DAVID S · 2012 to 2016
$25.8M
Research Desogn and Biostatistics CoreU54MD007588 · NIMHD · MOREHOUSE SCHOOL OF MEDICINE · PI MAYBERRY, ROBERT M · 2012 to 2018
$24.8M
Center for Clinical and Translational Sciences (CCTS)UL1TR000371 · NCATS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI MCPHERSON, DAVID D · 2012 to 2016
$13.4M
Heartland Institute for Clinical and Translational ResearchUL1TR000001 · NCATS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI BAROHN, RICHARD J. · 2012 to 2015
$13.0M
Harvard Clinical and Translational Science CenterKL2TR001100 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2013 to 2017
$8.5M
Instrumenting i2b2 for Improved Medication Research: Adding the Patient VoiceR01GM104303 · NIGMS · BOSTON CHILDREN'S HOSPITAL · PI MANDL, KENNETH D. · 2013 to 2016
$1.6M
Active Patient Participation in a Disease Registry for Comparative EffectivenessR01LM011185 · NLM · BOSTON CHILDREN'S HOSPITAL · PI MANDL, KENNETH D., WEITZMAN, ELISSA R · 2012 to 2014
$1.3M
Establishing Surveillance of the Pediatric Evidence Base for Drug TherapyR21HD072382 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI BOURGEOIS, FLORENCE, MANDL, KENNETH D. · 2012 to 2013
$479k
NCATS NIH HHS 1KL2TR001100,NCATS NIH HHS KL2 TR001100NCATS NIH HHS UL1 TR000001NCATS NIH HHS UL1 TR000371NCATS NIH HHS UL1 TR000454NCATS NIH HHS UL1TR000454NICHD NIH HHS R21 HD072382NIGMS NIH HHS R01 GM104303NIGMS NIH HHS R01GM104303NIMHD NIH HHS U54 MD007588NLM NIH HHS R01 LM011185NLM NIH HHS R01LM011185 ANDNLM NIH HHS U54 LM008748
6 · The paper itself

Abstract

We describe the architecture of the Patient Centered Outcomes Research Institute (PCORI) funded Scalable Collaborative Infrastructure for a Learning Healthcare System (SCILHS, http://www.SCILHS.org) clinical data research network, which leverages the $48 billion dollar federal investment in health information technology (IT) to enable a queryable semantic data model across 10 health systems covering more than 8 million patients, plugging universally into the point of care, generating evidence and discovery, and thereby enabling clinician and patient participation in research during the patient encounter. Central to the success of SCILHS is development of innovative 'apps' to improve PCOR research methods and capacitate point of care functions such as consent, enrollment, randomization, and outreach for patient-reported outcomes. SCILHS adapts and extends an existing national research network formed on an advanced IT infrastructure built with open source, free, modular components.

Indexed as

Computer Communication NetworksInformation DisseminationPatient-Centered CareElectronic Health RecordsHumansOrganizationsOutcome Assessment, Health CareUnited StatesClinical TrialsDistributed ComputingElectronic Health RecordLearning Health SystemPatient Engagement

Identifiers

PMID24821734
PMCPMC4078286

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.