Evidence map›Paper›PMID 24821701›Full record

ArticleHuman molecular genetics2014

Expression of an expanded CGG-repeat RNA in a single pair of primary sensory neurons impairs olfactory adaptation in Caenorhabditis elegans.

Bi-Tzen Juang, Anna L Ludwig, Kelli L Benedetti, Chen Gu, Kimberly Collins, Christopher Morales, Aarati Asundi, Torsten Wittmann, Noelle L'Etoile, Paul J Hagerman

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Human molecular genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.2field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Review
  6. Fragile X-associated tremor/ataxia syndrome.Annals of the New York Academy of Sciences · 2015
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Bi-Tzen JuangDepartment of Biological Science and Technology, National Chiao Tung University, Hsinchu 300, Taiwan.
Anna L LudwigDepartment of Biochemistry and Molecular Medicine, University of California, Davis, School of Medicine, Davis, CA 95616, USA.
Kelli L BenedettiDepartment of Cell and Tissue Biology, University of California, San Francisco, San Francisco, CA 94143, USA.
Chen GuDepartment of Cell and Tissue Biology, University of California, San Francisco, San Francisco, CA 94143, USA.
Kimberly CollinsDepartment of Cell and Tissue Biology, University of California, San Francisco, San Francisco, CA 94143, USA.
Christopher MoralesDepartment of Cell and Tissue Biology, University of California, San Francisco, San Francisco, CA 94143, USA.
Aarati AsundiDepartment of Cell and Tissue Biology, University of California, San Francisco, San Francisco, CA 94143, USA.
Torsten WittmannDepartment of Cell and Tissue Biology, University of California, San Francisco, San Francisco, CA 94143, USA.
Noelle L'EtoileDepartment of Cell and Tissue Biology, University of California, San Francisco, San Francisco, CA 94143, USA pjhagerman@ucdavis.edu noelle.letoile@ucsf.edu.
Paul J HagermanDepartment of Biochemistry and Molecular Medicine, University of California, Davis, School of Medicine, Davis, CA 95616, USA, MIND Institute, University of California, Davis, Health System, Sacramento, CA 95817, USA pjhagerman@ucdavis.edu noelle.letoile@ucsf.edu.
University of California, San Francisco · USNational Yang Ming Chiao Tung University · TWUC Davis Health System · USUniversity of California, Davis · US

Funding

GENETICS OF EUCARYOTIC AND PROCARYOTIC ORGANISMST32GM007810 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ASHRAFI, KAVEH, NARLIKAR, GEETA J · 1985 to 2020
$15.1M
Maximizing Opportunities for Research Excellence - Evaluation Training SupplementR25GM056847 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DUNCAN, D'ANNE S., SELLO, JASON K · 1998 to 2023
$14.1M
Olfactory memory acquisition consolidation and recallR01DC005991 · NIDCD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI L 'ETOILE, NOELLE D · 2005 to 2022
$7.1M
Expression of the Fragile X GeneR01HD040661 · NICHD · UNIVERSITY OF CALIFORNIA DAVIS · PI HAGERMAN, PAUL J · 2002 to 2016
$4.3M
NICHD NIH HHS R01 HD040661NIDCD NIH HHS R01 DC005991NIGMS NIH HHS R25 GM056847NIGMS NIH HHS R25 GM56847NIGMS NIH HHS T32 GM007810
6 · The paper itself

Abstract

Fragile X-associated tremor/ataxia syndrome (FXTAS) is a severe neurodegenerative disorder that affects carriers of premutation CGG-repeat expansion alleles of the fragile X mental retardation 1 (FMR1) gene; current evidence supports a causal role of the expanded CGG repeat within the FMR1 mRNA in the pathogenesis of FXTAS. Though the mRNA has been observed to induce cellular toxicity in FXTAS, the mechanisms are unclear. One common neurophysiological characteristic of FXTAS patients is their inability to properly attenuate their response to an auditory stimulus upon receipt of a small pre-stimulus. Therefore, to gain genetic and cell biological insight into FXTAS, we examined the effect of expanded CGG repeats on the plasticity of the olfactory response of the genetically tractable nematode, Caenorhabditis elegans (C. elegans). While C. elegans is innately attracted to odors, this response can be downregulated if the odor is paired with starvation. We found that expressing expanded CGG repeats in olfactory neurons interfered with this plasticity without affecting either the innate odor-seeking response or the olfactory neuronal morphology. Interrogation of three RNA regulatory pathways indicated that the expanded CGG repeats act via the C. elegans microRNA (miRNA)-specific Argonaute ALG-2 to diminish olfactory plasticity. This observation suggests that the miRNA-Argonaute pathway may play a pathogenic role in subverting neuronal function in FXTAS.

Indexed as

AnimalsAnimals, Genetically ModifiedArgonaute ProteinsAtaxiaButanonesCaenorhabditis elegansDisease Models, AnimalFragile X Messenger Ribonucleoprotein 1Fragile X SyndromeHumansNeuronal PlasticityOlfactory Receptor NeuronsSensory Receptor CellsSmellTremorTrinucleotide Repeat ExpansionArgonaute ProteinsButanonesFMR1 protein, humanFragile X Messenger Ribonucleoprotein 1

Identifiers

PMID24821701
PMCPMC4140470
OpenAlexW2100923263

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.