Evidence map›Paper›PMID 24821223›Full record

ArticleMolecular psychiatry2015

Genome-wide association study in obsessive-compulsive disorder: results from the OCGAS.

M Mattheisen, J F Samuels, Y Wang, B D Greenberg, A J Fyer, J T McCracken, D A Geller, D L Murphy, J A Knowles, M A Grados and 19 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular psychiatry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 170 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
170citing papers in PubMed, 8 pooled it
36.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

170 citing papers in PubMed, 8 syntheses or guidelines pooled it, 325 citations in OpenAlex.

  1. Pooled it
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  4. Genetics of OCD and Related Disorders; Searching for Shared Factors.Current topics in behavioral neurosciences · 2021
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  14. Rare protein-disrupting variants inmedRxiv : the preprint server for health sciences · 2026
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110 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors at 9 institutions in 4 countries.

M Mattheisen1] Department of Biomedicine and Center for Integrated Sequencing (iSEQ), Aarhus University, Aarhus, Denmark [2] Department of Biostatistics, Harvard School of Public Health, Boston, MA, USA [3] Department of Genomic Mathematics, University of Bonn, Bonn, Germany.
J F SamuelsDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Y WangDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
B D GreenbergDepartment of Psychiatry and Human Behavior, Brown Medical School, Providence, RI, USA.
A J FyerNew York State Psychiatric Institute, College of Physicians and Surgeons at Columbia University, New York, NY, USA.
J T McCrackenDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles School of Medicine, Los Angeles, CA, USA.
D A GellerDepartment of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
D L MurphyLaboratory of Clinical Science, National Institute of Mental Health, Bethesda, MD, USA.
J A KnowlesDepartment of Psychiatry and Behavioral SciencesKeck School of Medicine at the University of Southern California, Los Angeles, CA, USA.
M A GradosDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
M A RiddleDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
S A RasmussenDepartment of Psychiatry and Human Behavior, Brown Medical School, Providence, RI, USA.
N C McLaughlinDepartment of Psychiatry and Human Behavior, Brown Medical School, Providence, RI, USA.
E L NurmiDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles School of Medicine, Los Angeles, CA, USA.
K D AsklandDepartment of Psychiatry and Human Behavior, Brown Medical School, Providence, RI, USA.
H-D QinDivision of Intramural Research Program, National Institute of Mental Health, Unit of Statistical Genomics, Intramural Research Program, Bethesda, MD, USA.
B A CullenDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
J PiacentiniDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles School of Medicine, Los Angeles, CA, USA.
D L PaulsDepartment of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
O J BienvenuDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
S E Stewart1] Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA [2] Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada.
K-Y LiangDepartment of Mental Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA.
F S GoesDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
B MaherDepartment of Mental Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA.
A E PulverDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Y Y ShugartDivision of Intramural Research Program, National Institute of Mental Health, Unit of Statistical Genomics, Intramural Research Program, Bethesda, MD, USA.
D ValleInstitute of Human Genetics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
C Lange1] Department of Biostatistics, Harvard School of Public Health, Boston, MA, USA [2] Department of Genomic Mathematics, University of Bonn, Bonn, Germany.
G NestadtDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Johns Hopkins University · USBrown University · USHarvard University · USNational Institute of Mental Health · USUniversity of California, Los Angeles · USAarhus University · DKNew York Psychoanalytic Society and Institute · USUniversity of Bonn · DEUniversity of Southern California · US

Funding

OCD Collaborative Genetics Association StudyR01MH071507 · NIMH · JOHNS HOPKINS UNIVERSITY · PI NESTADT, GERALD · 2007 to 2010
$6.5M
The Genetics of Obsessive Compulsive Disorder and Related OCD Spectrum DisordersZIAMH000336 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI MURPHY, DENNIS L · 2009 to 2014
$4.8M
Obsessive-compulsive disorder (OCD) Collaborative Genetics Association StudyR01MH079489 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI GELLER, DANIEL A · 2007 to 2010
$3.4M
Developing new statisical methods to detect variants involved in complex diseaseZIAMH002929 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI YAO, YIN · 2011 to 2016
$2.6M
OCD Collaborative Genetics Association StudyR01MH079488 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI FYER, ABBY J · 2007 to 2010
$906k
Obsessive-compulsive disorder (OCD) Collaborative Genetics Association StudyR01MH079494 · NIMH · UNIVERSITY OF SOUTHERN CALIFORNIA · PI KNOWLES, JAMES A · 2007 to 2011
$840k
OCD Collaborative Genetics Association StudyR01MH079487 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MCCRACKEN, JAMES T. · 2007 to 2010
$797k
Next generation risk variant discovery in a highly penetrant OCD subtypeK23MH094613 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI NURMI, ERIKA L · 2011 to 2014
$721k
Intramural NIH HHSNIMH NIH HHS K23 MH094613NIMH NIH HHS MH071507NIMH NIH HHS MH079487NIMH NIH HHS MH079488NIMH NIH HHS MH079489NIMH NIH HHS MH079494NIMH NIH HHS R01 MH071507NIMH NIH HHS R01 MH079487NIMH NIH HHS R01 MH079488NIMH NIH HHS R01 MH079489NIMH NIH HHS R01 MH079494
6 · The paper itself

Abstract

Obsessive-compulsive disorder (OCD) is a psychiatric condition characterized by intrusive thoughts and urges and repetitive, intentional behaviors that cause significant distress and impair functioning. The OCD Collaborative Genetics Association Study (OCGAS) is comprised of comprehensively assessed OCD patients with an early age of OCD onset. After application of a stringent quality control protocol, a total of 1065 families (containing 1406 patients with OCD), combined with population-based samples (resulting in a total sample of 5061 individuals), were studied. An integrative analyses pipeline was utilized, involving association testing at single-nucleotide polymorphism (SNP) and gene levels (via a hybrid approach that allowed for combined analyses of the family- and population-based data). The smallest P-value was observed for a marker on chromosome 9 (near PTPRD, P=4.13 × 10(-)(7)). Pre-synaptic PTPRD promotes the differentiation of glutamatergic synapses and interacts with SLITRK3. Together, both proteins selectively regulate the development of inhibitory GABAergic synapses. Although no SNPs were identified as associated with OCD at genome-wide significance level, follow-up analyses of genome-wide association study (GWAS) signals from a previously published OCD study identified significant enrichment (P=0.0176). Secondary analyses of high-confidence interaction partners of DLGAP1 and GRIK2 (both showing evidence for association in our follow-up and the original GWAS study) revealed a trend of association (P=0.075) for a set of genes such as NEUROD6, SV2A, GRIA4, SLC1A2 and PTPRD. Analyses at the gene level revealed association of IQCK and C16orf88 (both P<1 × 10(-)(6), experiment-wide significant), as well as OFCC1 (P=6.29 × 10(-)(5)). The suggestive findings in this study await replication in larger samples.

Indexed as

Family HealthAdultChromosomes, Human, Pair 9Cooperative BehaviorFemaleFollow-Up StudiesGene Expression ProfilingGenetic Predisposition to DiseaseGenome-Wide Association StudyGenotypeHumansMaleObsessive-Compulsive DisorderOligonucleotide Array Sequence AnalysisPolymorphism, Single NucleotideReceptor-Like Protein Tyrosine Phosphatases, Class 2PTPRD protein, humanReceptor-Like Protein Tyrosine Phosphatases, Class 2

Identifiers

PMID24821223
PMCPMC4231023
OpenAlexW2007417768

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.