Evidence map›Paper›PMID 24821188›Full record

ArticlePloS one2014

Correlations between integrin ανβ6 expression and clinico-pathological features in stage B and stage C rectal cancer.

Seong Beom Ahn, Abidali Mohamedali, Charles Chan, Julie Fletcher, Sun Young Kwun, Candice Clarke, Owen F Dent, Pierre H Chapuis, Edouard Nice, Mark S Baker

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

  • Erratum issued
5 · Who and what money

Authors and funding

10 authors.

Seong Beom AhnAustralian School of Advanced Medicine, Macquarie University, North Ryde, New South Wales, Australia; Department of Chemistry and Biomolecular Sciences, Macquarie University, North Ryde, New South Wales, Australia.
Abidali MohamedaliAustralian School of Advanced Medicine, Macquarie University, North Ryde, New South Wales, Australia; Department of Chemistry and Biomolecular Sciences, Macquarie University, North Ryde, New South Wales, Australia.
Charles ChanDepartment of Anatomical Pathology, Concord Hospital, University of Sydney, Sydney, New South Wales, Australia.
Julie FletcherDepartment of Anatomical Pathology, Concord Hospital, University of Sydney, Sydney, New South Wales, Australia.
Sun Young KwunDepartment of Anatomical Pathology, Concord Hospital, University of Sydney, Sydney, New South Wales, Australia.
Candice ClarkeDepartment of Anatomical Pathology, Concord Hospital, University of Sydney, Sydney, New South Wales, Australia.
Owen F DentDepartment of Colorectal Surgery, Concord Hospital, University of Sydney, Sydney, New South Wales, Australia.
Pierre H ChapuisDepartment of Colorectal Surgery, Concord Hospital, University of Sydney, Sydney, New South Wales, Australia.
Edouard NiceDepartment of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia.
Mark S BakerAustralian School of Advanced Medicine, Macquarie University, North Ryde, New South Wales, Australia; Department of Chemistry and Biomolecular Sciences, Macquarie University, North Ryde, New South Wales, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Integrin ανβ6 is highly expressed in a range of human cancers and frequently correlates with patient survival. This study examines correlations between ανβ6 expression and patient clinico-pathological features in Stage B and Stage C rectal cancer, including overall survival. Expression of ανβ6 was measured in 362 Stage B or C rectal cancer tissue samples at the tumour central region, invasive tumour front and adjacent non-neoplastic mucosa using immunohistochemistry. Distribution of ανβ6 was found to be significantly higher at the invasive front compared to central regions of the tumour (p<0.001) or adjacent non-neoplastic mucosa (p<0.001) suggesting ανβ6 plays a role in tumour cell invasion. However, integrin ανβ6 expression was not associated with clinico-pathological features or overall survival indicating it is not an independent prognostic marker differentiating Stage B or C rectal cancer. Previous ανβ6 studies have suggested the expression of ανβ6 is involved in the earlier stages (i.e. Stages A/B) of tumour progression rather than the later stages (i.e. Stages C/D). However, our study has revealed that in rectal cancer ανβ6 expression does not increase between Stages B and C, but may occur earlier, namely before or during Stage B cancer.

Indexed as

Gene Expression Regulation, NeoplasticAdultAgedAged, 80 and overAntigens, NeoplasmHumansIntegrinsMaleMiddle AgedNeoplasm InvasivenessNeoplasm StagingRectal NeoplasmsSurvival AnalysisAntigens, Neoplasmintegrin alphavbeta6Integrins

Identifiers

PMID24821188
PMCPMC4018280

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.