Evidence map›Paper›PMID 24821143›Full record

Trial reportPloS one2014

Prolonged repeated acupuncture stimulation induces habituation effects in pain-related brain areas: an FMRI study.

Chuanfu Li, Jun Yang, Kyungmo Park, Hongli Wu, Sheng Hu, Wei Zhang, Junjie Bu, Chunsheng Xu, Bensheng Qiu, Xiaochu Zhang

Open access · goldAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 2 pooled it
10.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 33 citations in OpenAlex.

  1. Pooled it
  2. Acupuncture for neuropathic pain in adults.The Cochrane database of systematic reviews · 2017
    Pooled it
  3. Trial
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Neuroimaging Assessment of Pain.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2022
    Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. The Immediate Analgesic Effect of Acupuncture for Pain: A Systematic Review and Meta-Analysis.Evidence-based complementary and alternative medicine : eCAM · 2017
    Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Chuanfu LiLaboratory of Digital Medical Imaging, Medical Imaging Center, First Affiliated Hospital, Anhui University of Chinese Medicine, Hefei, Anhui, China.
Jun YangDepartment of Acupuncture and Moxibustion, First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, Anhui, China.
Kyungmo ParkDepartment of Biomedical Engineering, Kyung Hee University, Yongin, Republic of Korea.
Hongli WuCollege of Medical Information engineering, Anhui University of Chinese Medicine, Hefei, Anhui, China.
Sheng HuSchool of Information Science and Technology, University of Science and Technology of China, Hefei, Anhui, China.
Wei ZhangLaboratory of Digital Medical Imaging, Medical Imaging Center, First Affiliated Hospital, Anhui University of Chinese Medicine, Hefei, Anhui, China.
Junjie BuCAS Key Laboratory of Brain Function & Disease and School of Life Sciences, University of Science and Technology of China, Hefei, Anhui, China.
Chunsheng XuLaboratory of Digital Medical Imaging, Medical Imaging Center, First Affiliated Hospital, Anhui University of Chinese Medicine, Hefei, Anhui, China.
Bensheng QiuSchool of Information Science and Technology, University of Science and Technology of China, Hefei, Anhui, China.
Xiaochu ZhangCAS Key Laboratory of Brain Function & Disease and School of Life Sciences, University of Science and Technology of China, Hefei, Anhui, China.
Anhui University of Traditional Chinese Medicine · CNUniversity of Science and Technology of China · CNKyung Hee University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Most previous studies of brain responses to acupuncture were designed to investigate the acupuncture instant effect while the cumulative effect that should be more important in clinical practice has seldom been discussed. In this study, the neural basis of the acupuncture cumulative effect was analyzed. For this experiment, forty healthy volunteers were recruited, in which more than 40 minutes of repeated acupuncture stimulation was implemented at acupoint Zhusanli (ST36). Three runs of acupuncture fMRI datasets were acquired, with each run consisting of two blocks of acupuncture stimulation. Besides general linear model (GLM) analysis, the cumulative effects of acupuncture were analyzed with analysis of covariance (ANCOVA) to find the association between the brain response and the cumulative duration of acupuncture stimulation in each stimulation block. The experimental results showed that the brain response in the initial stage was the strongest although the brain response to acupuncture was time-variant. In particular, the brain areas that were activated in the first block and the brain areas that demonstrated cumulative effects in the course of repeated acupuncture stimulation overlapped in the pain-related areas, including the bilateral middle cingulate cortex, the bilateral paracentral lobule, the SII, and the right thalamus. Furthermore, the cumulative effects demonstrated bimodal characteristics, i.e. the brain response was positive at the beginning, and became negative at the end. It was suggested that the cumulative effect of repeated acupuncture stimulation was consistent with the characteristic of habituation effects. This finding may explain the neurophysiologic mechanism underlying acupuncture analgesia.

Indexed as

Habituation, PsychophysiologicMagnetic Resonance ImagingAcupuncture TherapyAdultBrainFemaleHumansMalePainPain ManagementTime FactorsYoung Adult

Identifiers

PMID24821143
PMCPMC4018444
OpenAlexW2017459671

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.