ArticleJournal of molecular evolution2014
Generation of oligonucleotides under hydrothermal conditions by non-enzymatic polymerization.
Article in Journal of molecular evolution, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
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Who cites it
55 citing papers in PubMed.
- Abiotic synthesis of RNase-resistant phosphodiester and pyrophosphate-linked polymers via thermodynamically controlled wet-dry cycling.Scientific reports · 2026Article
- Selection for growth drives the emergence of genetic heredity in protocells.PLoS biology · 2026Article
- Water Versus Land on Temperate Rocky Planets.Space science reviews · 2026Review
- The secret life of RNA and lipids.RNA biology · 2025Review
- Origin of the RNA World in Cold Hadean Geothermal Fields Enriched in Zinc and Potassium: Abiogenesis as a Positive Fallout from the Moon-Forming Impact?Life (Basel, Switzerland) · 2025Article
- Wet-dry cycles cause nucleic acid monomers to polymerize into long chains.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Perspective: Protocells and the Path to Minimal Life.Journal of molecular evolution · 2024Review
- The bubble theory: exploring the transition from first replicators to cells and viruses in a landscape-based scenario.Theory in biosciences = Theorie in den Biowissenschaften · 2024Article
- Microfluidics-Based Drying-Wetting Cycles to Investigate Phase Transitions of Small Molecules Solutions.Life (Basel, Switzerland) · 2024Article
- Crystallization as a selection force at the polymerization of nucleotides in a prebiotic context.iScience · 2023Article
- Template-Directed Replication and Chiral Resolution during Wet-Dry Cycling in Hydrothermal Pools.Life (Basel, Switzerland) · 2023Article
- Review
- The Formation of RNA Pre-Polymers in the Presence of Different Prebiotic Mineral Surfaces Studied by Molecular Dynamics Simulations.Life (Basel, Switzerland) · 2022Article
- Visualizing RNA polymers produced by hot wet-dry cycling.Scientific reports · 2022Article
- Sequencing the origins of life.BBA advances · 2022Review
- Evolution towards increasing complexity through functional diversification in a protocell model of the RNA world.Proceedings. Biological sciences · 2021Article
- Plausibility of Early Life in a Relatively Wide Temperature Range: Clues from Simulated Metabolic Network Expansion.Life (Basel, Switzerland) · 2021Article
- The "Water Problem"(Life (Basel, Switzerland) · 2021Review
- Where Did Life Begin? Testing Ideas in Prebiotic Analogue Conditions.Life (Basel, Switzerland) · 2021Article
- AFM Images of Viroid-Sized Rings That Self-Assemble from Mononucleotides through Wet-Dry Cycling: Implications for the Origin of Life.Life (Basel, Switzerland) · 2020Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We previously reported that 5'-mononucleotides organized within a multilamellar lipid matrix can produce oligomers in the anhydrous phase of hydration-dehydration (HD) cycles. However, hydrolysis of oligomers can occur during hydration, and it is important to better understand the steady state in which ester bond synthesis is balanced by hydrolysis. In order to study condensation products of mononucleotides and hydrolysis of their polymers, we established a simulation of HD cycles that would occur on the early Earth when volcanic land masses emerged from the ocean over 4 billion years ago. At this stage on early Earth, precipitation produced hydrothermal fields characterized by small aqueous pools undergoing evaporation and refilling at elevated temperatures. Here, we confirm that under these conditions, the chemical potential made available by cycles of hydration and dehydration is sufficient to drive synthesis of ester bonds. If 5'-mononucleotides are in solution at millimolar concentrations, then oligomers resembling RNA are synthesized and exist in a steady state with their monomers. Furthermore, if the mononucleotides can form complementary base pairs, then some of the products have properties suggesting that secondary structures are present, including duplex species stabilized by hydrogen bonds.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.