ArticleNeuroradiology2014
Thalamic metabolic alterations with cognitive dysfunction in idiopathic trigeminal neuralgia: a multivoxel spectroscopy study.
Article in Neuroradiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Electroencephalographic Patterns in Chronic Pain: A Systematic Review of the Literature.PloS one · 2016Pooled it
- 3D magnetic resonance spectroscopic imaging reveals links between brain metabolites and multidimensional pain features in fibromyalgia.European journal of pain (London, England) · 2021Article
- The thalamus in trigeminal neuralgia: structural and metabolic abnormalities, and influence on surgical response.BMC neurology · 2021Article
- First application of 7-T ultra-high field diffusion tensor imaging to detect altered microstructure of thalamic-somatosensory anatomy in trigeminal neuralgia.Journal of neurosurgery · 2020Article
- A modified Hodgkin-Huxley model to show the effect of motor cortex stimulation on the trigeminal neuralgia network.Journal of mathematical neuroscience · 2019Article
- Alterations of Dynamic Regional Homogeneity in Trigeminal Neuralgia: A Resting-State fMRI Study.Frontiers in neurology · 2019Article
- Altered structure and functional connection in patients with classical trigeminal neuralgia.Human brain mapping · 2018Article
- Acupuncture therapy in treating migraine: results of a magnetic resonance spectroscopy imaging study.Journal of pain research · 2018Article
- Spatial-temporal signature of resting-state BOLD signals in classic trigeminal neuralgia.Journal of pain research · 2017Article
- Metabolic Imaging in Humans.Topics in magnetic resonance imaging : TMRI · 2016Review
- Altered regional homogeneity of spontaneous brain activity in idiopathic trigeminal neuralgia.Neuropsychiatric disease and treatment · 2015Article
- Brain Wave Patterns in Patients With Chronic Low Back Pain: A Case-control Study.Basic and clinical neuroscienceArticle
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7 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
introductionAlthough abnormalities in metabolite compositions in the thalamus are well described in patients with idiopathic trigeminal neuralgia (ITN), differences in distinct thalamic subregions have not been measured with proton magnetic resonance spectroscopy ((1)H-MRS), and whether there are correlations between thalamic metabolites and cognitive function still remain unknown.
methodsMultivoxel MRS was recorded to investigate the metabolic alterations in the thalamic subregions of patients with ITN. The regions of interest were localized in the anterior thalamus (A-Th), intralaminar portion of the thalamus (IL-Th), posterior lateral thalamus (PL-Th), posterior medial thalamus (PM-Th), and medial and lateral pulvinar of the thalamus (PuM-Th and PuL-Th). The N-acetylaspartate to creatine (NAA/Cr) and choline to creatine (Cho/Cr) ratios were measured in the ITN and control groups. Scores of the visual analogue scale (VAS) and the Montreal Cognitive Assessment (MoCA) were analyzed to correlate with the neuroradiological findings.
resultsThe NAA/Cr ratio in the affected side of PM-Th and PL-Th in ITN patients was statistically lower than that in the corresponding regions of the thalamus in controls. The NAA/Cr ratio in the affected PM-Th was negatively associated with VAS and disease duration. Furthermore, decreases of NAA/Cr and Cho/Cr were detected in the affected side of IL-Th, and lower Cho/Cr was positively correlated with MoCA values in the ITN group.
conclusionsOur result of low level of NAA/Cr in the affected PM-Th probably serves as a marker of the pain-rating index, and decreased Cho/Cr in IL-Th may be an indicator of cognitive disorder in patients with ITN.
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