Evidence map›Paper›PMID 24820620›Full record

ArticleMolecular bioSystems2014

A role for hydrogen bonding in DNA recognition by the non-classical CCHHC type zinc finger, NZF-1.

Angelique N Besold, Deborah L Amick, Sarah L J Michel

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular bioSystems, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Angelique N BesoldDepartment of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, Maryland 21201, USA. smichel@rx.umaryland.edu.
Deborah L Amick
Sarah L J Michel
University of Baltimore · USUniversity of Maryland, Baltimore · USUniversity of Maryland, College Park · US

Funding

Zinc finger proteins involved in neuronal developmentF31NS074768 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI BESOLD, ANGELIQUE NICOLE · 2011 to 2013
$86k
NINDS NIH HHS F31 NS074768NINDS NIH HHS F31NS074768
6 · The paper itself

Abstract

The non-classical zinc finger protein, Neural Zinc Finger Factor-1, contains six Cys2His2Cys domains. All three cysteines and the second histidine directly bind Zn(II). Using a combination of mutagenesis, metal coordination and DNA binding studies, we report that the first histidine is involved in a functionally important hydrogen bonding interaction.

Indexed as

AnimalsBinding SitesCysteineDNAHistidineHumansHydrogen BondingModels, MolecularMutationNerve Tissue ProteinsTranscription FactorsZinc FingersCysteineDNAHistidineMYT1L protein, humanNerve Tissue ProteinsTranscription Factors

Identifiers

PMID24820620
PMCPMC4066409
OpenAlexW2116113538

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.