Evidence map›Paper›PMID 24820538›Full record

ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2014

Sex differences in COMT polymorphism effects on prefrontal inhibitory control in adolescence.

Thomas P White, Eva Loth, Katya Rubia, Lydia Krabbendam, Robert Whelan, Tobias Banaschewski, Gareth J Barker, Arun L W Bokde, Christian Büchel, Patricia Conrod and 20 more

Open access · bronzeAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 3 pooled it
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 3 syntheses or guidelines pooled it, 57 citations in OpenAlex.

  1. International journal of molecular sciences · 2022
    Pooled it
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  15. No association ofPeerJ · 2019
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  19. Frontiers in genetics · 2018
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors at 14 institutions in 6 countries.

Thomas P WhiteDepartment of Psychosis Studies, Institute of Psychiatry, King's College London, London, UK.
Eva LothMRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, London, UK.
Katya RubiaDepartment of Child and Adolescent Psychiatry, Institute of Psychiatry, King's College London, London, UK.
Lydia KrabbendamDepartment of Educational Neuroscience, Faculty of Psychology and Education, VU University Amsterdam, Amsterdam, The Netherlands.
Robert Whelan1] Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland [2] Departments of Psychiatry and Psychology, University of Vermont, Burlington, VT, USA.
Tobias BanaschewskiDepartment of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Gareth J BarkerInstitute of Psychiatry, King's College London, London, UK.ORCID 0000000252147421
Arun L W BokdeInstitute of Neuroscience and Discipline of Psychiatry, School of Medicine, Trinity College Dublin, Dublin, Ireland.
Christian BüchelUniversitaetsklinikum Hamburg Eppendorf, Hamburg, Germany.
Patricia Conrod1] Institute of Psychiatry, King's College London, London, UK [2] Department of Psychiatry, Universite de Montreal, CHU Ste Justine Hospital, Montreal, QC, Canada.
Mira Fauth-Bühler1] Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany [2] Department of Addictive Behaviour and Addiction Medicine, Heidelberg University, Heidelberg, Germany.
Herta FlorDepartment of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Vincent FrouinNeurospin, Commissariat à l'Energie Atomique et aux Energies Alternatives, Paris, France.
Jürgen GallinatDepartment of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Hugh Garavan1] Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland [2] Departments of Psychiatry and Psychology, University of Vermont, Burlington, VT, USA.
Penny GowlandDepartment of Physics and Astronomy, University of Nottingham, Nottingham, UK.
Andreas HeinzDepartment of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Bernd IttermannPhysikalisch-Technische Bundesanstalt (PTB), Braunschweig und Berlin, Berlin, Germany.
Claire LawrenceSchool of Psychology, University of Nottingham, Nottingham, UK.
Karl MannDepartment of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Marie-Laure Paillère1] Institut National de la Santé et de la Recherche Médicale, INSERM CEA Unit 1000 'Imaging & Psychiatry', University Paris Sud, Orsay, France [2] AP-HP Department of Adolescent Psychopathology and Medicine, Maison de Solenn, University Paris Descartes, Paris, France.
Frauke NeesInstitute of Neuroscience, Trinity College Dublin, Dublin, Ireland.
Tomas Paus1] School of Psychology, University of Nottingham, Nottingham, UK [2] Rotman Research Institute, University of Toronto, Toronto, ON, Canada [3] Montreal Neurological Institute, McGill University, Montreal, QC, Canada.
Zdenka PausovaThe Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
Marcella RietschelDepartment of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Trevor RobbinsBehavioural and Clinical Neurosciences Institute, Department of Experimental Psychology, University of Cambridge, Cambridge, UK.
Michael N SmolkaDepartment of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Dresden, Germany.
Sukhwinder S ShergillDepartment of Psychosis Studies, Institute of Psychiatry, King's College London, London, UK.
Gunter SchumannMRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, London, UK.
IMAGEN Consortium
King's College London · GBHeidelberg University · DETrinity College Dublin · IECharité - Universitätsmedizin Berlin · DEUniversity of Nottingham · GBCommissariat à l'Énergie Atomique et aux Énergies Alternatives · FRDélégation Paris 5 · FREppendorf (Germany) · DEMontreal Neurological Institute and Hospital · CAPhysikalisch-Technische Bundesanstalt · DETechnische Universität Dresden · DEUniversity of Cambridge · GBUniversity of Toronto · CAUniversity of Vermont · US

Funding

Medical Research Council G0901858Medical Research Council G0901868
6 · The paper itself

Abstract

Catecholamine-0-methyl-transferase (COMT) gene variation effects on prefrontal blood oxygenation-level-dependent (BOLD) activation are robust; however, despite observations that COMT is estrogenically catabolized, sex differences in its prefrontal repercussions remain unclear. Here, in a large sample of healthy adolescents stratified by sex and Val(158)Met genotype (n=1133), we examine BOLD responses during performance of the stop-signal task in right-hemispheric prefrontal regions fundamental to inhibitory control. A significant sex-by-genotype interaction was observed in pre-SMA during successful-inhibition trials and in both pre-SMA and inferior frontal cortex during failed-inhibition trials with Val homozygotes displaying elevated activation compared with other genotypes in males but not in females. BOLD activation in the same regions significantly mediated the relationship between COMT genotype and inhibitory proficiency as indexed by stop-signal reaction time in males alone. These sexually dimorphic effects of COMT on inhibitory brain activation have important implications for our understanding of the contrasting patterns of prefrontally governed psychopathology observed in males and females.

Indexed as

Inhibition, PsychologicalPolymorphism, GeneticSex CharacteristicsAdolescentCatechol O-MethyltransferaseCerebrovascular CirculationExecutive FunctionFemaleHumansMagnetic Resonance ImagingMaleNeuropsychological TestsOxygenPrefrontal CortexPsychomotor PerformanceReaction TimeCatechol O-MethyltransferaseCOMT protein, humanOxygen

Identifiers

PMID24820538
PMCPMC4207335
OpenAlexW2134685023

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.