ArticleMolecular and cellular biology2014
Casein kinase 1 promotes synchrony of the circadian clock network.
Article in Molecular and cellular biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 22 citations in OpenAlex.
- Review
- Post-Translational Modifications in Animal Circadian Clocks.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Article
- Investigation of metal ion binding biomolecules one molecule at a time.Frontiers in chemistry · 2024Review
- Diurnal circadian clock gene expression is altered in models of genetic and acquired epilepsy.Epilepsia open · 2023Article
- Extensive tissue-specific expression variation and novel regulators underlying circadian behavior.Science advances · 2021Article
- The interaction of the circadian and immune system: Desynchrony as a pathological outcome to traumatic brain injury.Neurobiology of sleep and circadian rhythms · 2020Review
- A Symphony of Signals: Intercellular and Intracellular Signaling Mechanisms Underlying Circadian Timekeeping in Mice and Flies.International journal of molecular sciences · 2019Review
- An Overview of the Polymorphisms of Circadian Genes Associated With Endocrine Cancer.Frontiers in endocrinology · 2019Review
- Circadian Rhythms and Sleep inGenetics · 2017Review
- Prepartal Energy Intake Alters Blood Polymorphonuclear Leukocyte Transcriptome During the Peripartal Period in Holstein Cows.Bioinformatics and biology insights · 2017Article
- The molecular ticks of the Drosophila circadian clock.Current opinion in insect science · 2015Article
- Drosophila TIM binds importin α1, and acts as an adapter to transport PER to the nucleus.PLoS genetics · 2015Article
- Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Casein kinase 1, known as DOUBLETIME (DBT) in Drosophila melanogaster, is a critical component of the circadian clock that phosphorylates and promotes degradation of the PERIOD (PER) protein. However, other functions of DBT in circadian regulation are not clear, in part because severe reduction of dbt causes preadult lethality. Here we report the molecular and behavioral phenotype of a viable dbt(EY02910) loss-of-function mutant. We found that DBT protein levels are dramatically reduced in adult dbt(EY02910) flies, and the majority of mutant flies display arrhythmic behavior, with a few showing weak, long-period (∼32 h) rhythms. Peak phosphorylation of PER is delayed, and both hyper- and hypophosphorylated forms of the PER and CLOCK proteins are present throughout the day. In addition, molecular oscillations of the circadian clock are dampened. In the central brain, PER and TIM expression is heterogeneous and decoupled in the canonical clock neurons of the dbt(EY02910) mutants. We also report an interaction between dbt and the signaling pathway involving pigment dispersing factor (PDF), a synchronizing peptide in the clock network. These data thus demonstrate that overall reduction of DBT causes long and arrhythmic behavior, and they reveal an unexpected role of DBT in promoting synchrony of the circadian clock network.
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