Evidence map›Paper›PMID 24820025›Full record

ArticlePlant physiology2014

A Functional Antagonistic Relationship between Auxin and Mitochondrial Retrograde Signaling Regulates Alternative Oxidase1a Expression in Arabidopsis.

Aneta Ivanova, Simon R Law, Reena Narsai, Owen Duncan, Jae-Hoon Lee, Botao Zhang, Olivier Van Aken, Jordan D Radomiljac, Margaretha van der Merwe, KeKe Yi and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Plant physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed
9.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 110 citations in OpenAlex.

  1. Article
  2. Perturbation of mitochondrial CaStress biology · 2026
    Article
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  5. Review
  6. Article
  7. Article
  8. Phytohormones as Regulators of Mitochondrial Gene Expression inInternational journal of molecular sciences · 2023
    Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Mitochondrial GPAT-derived LPA controls auxin-dependent embryonic and postembryonic development.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  14. Article
  15. Article
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  17. Review
  18. Article
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  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Aneta IvanovaAustralian Research Council Centre of Excellence in Plant Energy Biology, Department of Botany, School of Life Science, La Trobe University, Bundoora, Victoria 3086, Australia (A.I., S.R.L., O.D., B.Z., J.D.R., J.W.);Australian Research Council Centre of Excellence in Plant Energy Biology, University of Western Australia, Crawley, Western Australia 6009, Australia (A.I., R.N., J.-H.L., O.V.A., J.D.R., M.v.d.M.); andState Key Laboratory Breeding Base for Zhejiang Sustainable Pest and Disease Control, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China (K.Y.).
Simon R LawAustralian Research Council Centre of Excellence in Plant Energy Biology, Department of Botany, School of Life Science, La Trobe University, Bundoora, Victoria 3086, Australia (A.I., S.R.L., O.D., B.Z., J.D.R., J.W.);Australian Research Council Centre of Excellence in Plant Energy Biology, University of Western Australia, Crawley, Western Australia 6009, Australia (A.I., R.N., J.-H.L., O.V.A., J.D.R., M.v.d.M.); andState Key Laboratory Breeding Base for Zhejiang Sustainable Pest and Disease Control, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China (K.Y.).
Reena NarsaiAustralian Research Council Centre of Excellence in Plant Energy Biology, Department of Botany, School of Life Science, La Trobe University, Bundoora, Victoria 3086, Australia (A.I., S.R.L., O.D., B.Z., J.D.R., J.W.);Australian Research Council Centre of Excellence in Plant Energy Biology, University of Western Australia, Crawley, Western Australia 6009, Australia (A.I., R.N., J.-H.L., O.V.A., J.D.R., M.v.d.M.); andState Key Laboratory Breeding Base for Zhejiang Sustainable Pest and Disease Control, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China (K.Y.).
Owen DuncanAustralian Research Council Centre of Excellence in Plant Energy Biology, Department of Botany, School of Life Science, La Trobe University, Bundoora, Victoria 3086, Australia (A.I., S.R.L., O.D., B.Z., J.D.R., J.W.);Australian Research Council Centre of Excellence in Plant Energy Biology, University of Western Australia, Crawley, Western Australia 6009, Australia (A.I., R.N., J.-H.L., O.V.A., J.D.R., M.v.d.M.); andState Key Laboratory Breeding Base for Zhejiang Sustainable Pest and Disease Control, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China (K.Y.).
Jae-Hoon LeeAustralian Research Council Centre of Excellence in Plant Energy Biology, Department of Botany, School of Life Science, La Trobe University, Bundoora, Victoria 3086, Australia (A.I., S.R.L., O.D., B.Z., J.D.R., J.W.);Australian Research Council Centre of Excellence in Plant Energy Biology, University of Western Australia, Crawley, Western Australia 6009, Australia (A.I., R.N., J.-H.L., O.V.A., J.D.R., M.v.d.M.); andState Key Laboratory Breeding Base for Zhejiang Sustainable Pest and Disease Control, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China (K.Y.).
Botao ZhangAustralian Research Council Centre of Excellence in Plant Energy Biology, Department of Botany, School of Life Science, La Trobe University, Bundoora, Victoria 3086, Australia (A.I., S.R.L., O.D., B.Z., J.D.R., J.W.);Australian Research Council Centre of Excellence in Plant Energy Biology, University of Western Australia, Crawley, Western Australia 6009, Australia (A.I., R.N., J.-H.L., O.V.A., J.D.R., M.v.d.M.); andState Key Laboratory Breeding Base for Zhejiang Sustainable Pest and Disease Control, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China (K.Y.).
Olivier Van AkenAustralian Research Council Centre of Excellence in Plant Energy Biology, Department of Botany, School of Life Science, La Trobe University, Bundoora, Victoria 3086, Australia (A.I., S.R.L., O.D., B.Z., J.D.R., J.W.);Australian Research Council Centre of Excellence in Plant Energy Biology, University of Western Australia, Crawley, Western Australia 6009, Australia (A.I., R.N., J.-H.L., O.V.A., J.D.R., M.v.d.M.); andState Key Laboratory Breeding Base for Zhejiang Sustainable Pest and Disease Control, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China (K.Y.).
Jordan D RadomiljacAustralian Research Council Centre of Excellence in Plant Energy Biology, Department of Botany, School of Life Science, La Trobe University, Bundoora, Victoria 3086, Australia (A.I., S.R.L., O.D., B.Z., J.D.R., J.W.);Australian Research Council Centre of Excellence in Plant Energy Biology, University of Western Australia, Crawley, Western Australia 6009, Australia (A.I., R.N., J.-H.L., O.V.A., J.D.R., M.v.d.M.); andState Key Laboratory Breeding Base for Zhejiang Sustainable Pest and Disease Control, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China (K.Y.).
Margaretha van der MerweAustralian Research Council Centre of Excellence in Plant Energy Biology, Department of Botany, School of Life Science, La Trobe University, Bundoora, Victoria 3086, Australia (A.I., S.R.L., O.D., B.Z., J.D.R., J.W.);Australian Research Council Centre of Excellence in Plant Energy Biology, University of Western Australia, Crawley, Western Australia 6009, Australia (A.I., R.N., J.-H.L., O.V.A., J.D.R., M.v.d.M.); andState Key Laboratory Breeding Base for Zhejiang Sustainable Pest and Disease Control, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China (K.Y.).
KeKe YiAustralian Research Council Centre of Excellence in Plant Energy Biology, Department of Botany, School of Life Science, La Trobe University, Bundoora, Victoria 3086, Australia (A.I., S.R.L., O.D., B.Z., J.D.R., J.W.);Australian Research Council Centre of Excellence in Plant Energy Biology, University of Western Australia, Crawley, Western Australia 6009, Australia (A.I., R.N., J.-H.L., O.V.A., J.D.R., M.v.d.M.); andState Key Laboratory Breeding Base for Zhejiang Sustainable Pest and Disease Control, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China (K.Y.).
James WhelanAustralian Research Council Centre of Excellence in Plant Energy Biology, Department of Botany, School of Life Science, La Trobe University, Bundoora, Victoria 3086, Australia (A.I., S.R.L., O.D., B.Z., J.D.R., J.W.);Australian Research Council Centre of Excellence in Plant Energy Biology, University of Western Australia, Crawley, Western Australia 6009, Australia (A.I., R.N., J.-H.L., O.V.A., J.D.R., M.v.d.M.); andState Key Laboratory Breeding Base for Zhejiang Sustainable Pest and Disease Control, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China (K.Y.) j.whelan@latrobe.edu.au.
Australian Research Council · AULa Trobe University · AUUniversity of Western Australia · AUZheJiang Academy of Agricultural Sciences · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The perception and integration of stress stimuli with that of mitochondrion function are important during periods of perturbed cellular homeostasis. In a continuous effort to delineate these mitochondrial/stress-interacting networks, forward genetic screens using the mitochondrial stress response marker alternative oxidase 1a (AOX1a) provide a useful molecular tool to identify and characterize regulators of mitochondrial stress signaling (referred to as regulators of alternative oxidase 1a [RAOs] components). In this study, we reveal that mutations in genes coding for proteins associated with auxin transport and distribution resulted in a greater induction of AOX1a in terms of magnitude and longevity. Three independent mutants for polarized auxin transport, rao3/big, rao4/pin-formed1, and rao5/multidrug-resistance1/abcb19, as well as the Myb transcription factor rao6/asymmetric leaves1 (that displays altered auxin patterns) were identified and resulted in an acute sensitivity toward mitochondrial dysfunction. Induction of the AOX1a reporter system could be inhibited by the application of auxin analogs or reciprocally potentiated by blocking auxin transport. Promoter activation studies with AOX1a::GUS and DR5::GUS lines further confirmed a clear antagonistic relationship between the spatial distribution of mitochondrial stress and auxin response kinetics, respectively. Genome-wide transcriptome analyses revealed that mitochondrial stress stimuli, such as antimycin A, caused a transient suppression of auxin signaling and conversely, that auxin treatment repressed a part of the response to antimycin A treatment, including AOX1a induction. We conclude that mitochondrial stress signaling and auxin signaling are reciprocally regulated, balancing growth and stress response(s).

Identifiers

PMID24820025
PMCPMC4081334
OpenAlexW2113789466

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.