ArticlePloS one2014
Single nucleotide polymorphism in ATM gene, cooking oil fumes and lung adenocarcinoma susceptibility in Chinese female non-smokers: a case-control study.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 3 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 3 syntheses or guidelines pooled it, 26 citations in OpenAlex.
- Pooled it
- ATM rs189037 (G > A) polymorphism increased the risk of cancer: an updated meta-analysis.BMC medical genetics · 2019Pooled it
- Association between ATM gene polymorphisms, lung cancer susceptibility and radiation-induced pneumonitis: a meta-analysis.BMC pulmonary medicine · 2017Pooled it
- Cytogenetic Consequences of Food Industry Workers Occupationally Exposed to Cooking Oil Fumes (COFs).Asian Pacific journal of cancer prevention : APJCP · 2021Article
- Lung cancer occurrence attributable to passive smoking among never smokers in China: a systematic review and meta-analysis.Translational lung cancer research · 2020Article
- The association ofJournal of Cancer · 2019Article
- Interaction Between Environmental Risk Factors and Catechol-O-Methyltransferase (COMT) and X-Ray Repair Cross-Complementing Protein 1 (XRCC1) Gene Polymorphisms in Risk of Lung Cancer Among Non-Smoking Chinese Women: A Case-Control Study.Medical science monitor : international medical journal of experimental and clinical research · 2018Article
- The role of the ataxia telangiectasia mutated gene in lung cancer: recent advances in research.Therapeutic advances in respiratory disease · 2017Review
- Gene mutation discovery research of non-smoking lung cancer patients due to indoor radon exposure.Annals of occupational and environmental medicine · 2016Review
- ATM rs189037 (G > A) polymorphism and risk of lung cancer and head and neck cancer: A meta-analysis.Meta gene · 2015Review
- TGFβ-1 and TGFBR2 polymorphisms, cooking oil fume exposure and risk of lung adenocarcinoma in Chinese nonsmoking females: a case control study.BMC medical genetics · 2015Article
- The role of mitochondrial tRNA mutations in lung cancer.International journal of clinical and experimental medicine · 2015Article
- Time Trends in Epidemiologic Characteristics and Imaging Features of Lung Adenocarcinoma: A Population Study of 21,113 Cases in China.PloS one · 2015Article
- Article
- Lung cancer molecular epidemiology in China: recent trends.Translational lung cancer research · 2014Review
- Effect of single nucleotide polymorphism Rs189037 in ATM gene on risk of lung cancer in Chinese: a case-control study.PloS one · 2014Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe ataxia-telangiectasia mutated (ATM) gene plays an important role in the DNA double-strand breaks repair pathway. Single nucleotide polymorphisms (SNPs) of DNA repair genes are suspected to influence the risk of lung cancer. This study aimed to investigate the association between the ATM -111G>A (rs189037) polymorphism, environmental risk factors and the risk of lung adenocarcinoma in Chinese female non-smokers.
methodsA hospital-based case-control study of 487 lung cancer patients and 516 matched cancer-free controls was conducted. Information concerning demographic and environmental risk factors was obtained for each case and control by a trained interviewer. After informed consent was obtained, 10 ml venous blood was collected from each subject for biomarker testing. Single nucleotide polymorphism was determined by using TaqMan method.
resultsThis study showed that the individuals with ATM rs189037 AA genotype were at an increased risk for lung adenocarcinoma compared with those carrying the GA or GG genotype (adjusted odds ratios (OR) 1.44, 95% confidence interval (CI) 1.02-2.02, P = 0.039). The stratified analysis suggested that increased risk associated with ATM rs189037 AA genotype in individuals who never or seldom were exposed to cooking oil fumes (adjusted OR 1.89, 95%CI 1.03-3.49, P = 0.040).
conclusionsATM rs189037 might be associated with the risk of lung adenocarcinoma in Chinese non-smoking females. Furthermore, ATM rs189037 AA genotype might be a risk factor of lung adenocarcinoma among female non-smokers without cooking oil fume exposure.
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