Evidence map›Paper›PMID 24819153›Full record

ArticleInternational journal of legal medicine2014

Dityrosine, a protein product of oxidative stress, as a possible marker of acute myocardial infarctions.

Felix Mayer, Sarah Pröpper, Stefanie Ritz-Timme

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Article in International journal of legal medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 3 pooled it
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 3 syntheses or guidelines pooled it, 29 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Felix MayerInstitute for Legal Medicine at the University Hospital Düsseldorf, Moorenstr. 5, 40225, Dusseldorf, Germany, felix.mayer@med.uni-duesseldorf.de.
Sarah Pröpper
Stefanie Ritz-Timme
Düsseldorf University Hospital · DEHeinrich Heine University Düsseldorf · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The verification of acute and lethal myocardial infarctions remains a crucial problem in the daily routine work of legal medicine. In order to enhance the possibilities in micromorphologic diagnostics, we investigated if dityrosine as a protein product of oxidative stress can be detected in myocardial tissue after an infarction and, if so, if it occurs early enough to be used in the diagnosis of infarctions with a short survival time. We examined tissue samples from 61 autopsy cases (37 male, 24 female) with verified or suspected infarctions as well as 11 control cases (7 male, 4 female). Immunohistochemical staining was performed for dityrosine and the established markers fibronectin and C5b-9. Positive staining for dityrosine was obtained in nearly all cases with infarctions aged 4 h to 2 weeks. Single positive results were obtained in cases with older (up to 2 months) or assumedly very fresh (up to 4 h) infarctions. Furthermore, single positive results with a different staining pattern were obtained in the control group. We concluded that dityrosine as a marker of oxidative stress can be detected after infarctions and might occur early enough to be helpful in the diagnosis of infarctions with a short survival time. Though dityrosine does not seem to be specific for infarctions, the different staining patterns enable a differentiation.

Indexed as

AdolescentAdultAgedAged, 80 and overBiomarkersCase-Control StudiesChildChild, PreschoolComplement Membrane Attack ComplexFemaleFibronectinsHumansImmunohistochemistryMaleMiddle AgedMyocardial InfarctionBiomarkersComplement Membrane Attack ComplexdityrosineFibronectinsTyrosine

Identifiers

PMID24819153
OpenAlexW2092135409

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.