Evidence map›Paper›PMID 24819031›Full record

ReviewCurrent problems in pediatric and adolescent health care

Adolescent fatigue, POTS, and recovery: a guide for clinicians.

Sarah J Kizilbash, Shelley P Ahrens, Barbara K Bruce, Gisela Chelimsky, Sherilyn W Driscoll, Cynthia Harbeck-Weber, Robin M Lloyd, Kenneth J Mack, Dawn E Nelson, Nelly Ninis and 4 more

Registry-linked trialOpen access · greenAbstract readReview
In one paragraph

Review in Current problems in pediatric and adolescent health care. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03974737 (Evaluation of the Compensatory Reserve Index and Psychosocial Factors in Pediatric Autonomic Dysfunction), which is not on this map. Cited by 55 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed, 1 pooled it
8.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03974737 completednot on this map

Evaluation of the Compensatory Reserve Index and Psychosocial Factors in Pediatric Autonomic Dysfunction

TypeobservationalSponsorUniversity of Colorado, DenverRan2019 to 2020Enrolled77ConditionsPostural Orthostatic Tachycardia SyndromeArmsCRI device (non-invasive vitals sign measurement)
3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 1 synthesis or guideline pooled it, 117 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Hemodynamic and cerebral oxygenation predictors of visual darkening in pediatric POTS: a cross-sectional study.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2026
    Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Can standing replace upright tilt table testing in the diagnosis of postural tachycardia syndrome (POTS) in the young?Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2025
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Sarah J KizilbashDepartment of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN.
Shelley P AhrensDepartment of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN.
Barbara K BruceDepartment of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN.
Gisela ChelimskyDepartment of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN.
Sherilyn W DriscollDepartment of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN.
Cynthia Harbeck-WeberDepartment of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN.
Robin M LloydDepartment of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN.
Kenneth J MackDepartment of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN.
Dawn E NelsonDepartment of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN.
Nelly NinisDepartment of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN.
Paolo T PianosiDepartment of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN.
Julian M StewartDepartment of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN.
Karen E WeissDepartment of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN.
Philip R FischerDepartment of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN.
Mayo Clinic in Florida · US

Funding

Local Vasoconstriction in Postural Tachycardia SyndromeR01HL074873 · NHLBI · NEW YORK MEDICAL COLLEGE · PI STEWART, JULIAN M · 2004 to 2013
$3.4M
NHLBI NIH HHS R01 HL074873
6 · The paper itself

Abstract

Many teenagers who struggle with chronic fatigue have symptoms suggestive of autonomic dysfunction that may include lightheadedness, headaches, palpitations, nausea, and abdominal pain. Inadequate sleep habits and psychological conditions can contribute to fatigue, as can concurrent medical conditions. One type of autonomic dysfunction, postural orthostatic tachycardia syndrome, is increasingly being identified in adolescents with its constellation of fatigue, orthostatic intolerance, and excessive postural tachycardia (more than 40 beats/min). A family-based approach to care with support from a multidisciplinary team can diagnose, treat, educate, and encourage patients. Full recovery is possible with multi-faceted treatment. The daily treatment plan should consist of increased fluid and salt intake, aerobic exercise, and regular sleep and meal schedules; some medications can be helpful. Psychological support is critical and often includes biobehavioral strategies and cognitive-behavioral therapy to help with symptom management. More intensive recovery plans can be implemented when necessary.

Indexed as

AdolescentAutonomic Nervous SystemCognitive Behavioral TherapyDizzinessExerciseFatigue Syndrome, ChronicFemaleHumansMaleOrthostatic IntolerancePostural Orthostatic Tachycardia SyndromePractice Guidelines as TopicRisk FactorsSyncope

Identifiers

PMID24819031
PMCPMC5819886
OpenAlexW2002273400

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.