Evidence map›Paper›PMID 24818944›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2014

Assessing Pseudomonas aeruginosa Persister/antibiotic tolerant cells.

Ronen Hazan, Damien Maura, Yok Ai Que, Laurence G Rahme

Abstract read
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Article
  2. Article
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  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Genome Analysis ofPathogens (Basel, Switzerland) · 2023
    Article
  10. PurN Is Involved in Antibiotic Tolerance and Virulence inAntibiotics (Basel, Switzerland) · 2022
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ronen HazanDepartment of Surgery, Harvard Medical School, Boston, MA, USA.
Damien Maura
Yok Ai Que
Laurence G Rahme

Funding

Interruption of Signaling-Mediated Bacterial Persistent InfectionsR33AI105902 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI RAHME, LAURENCE G · 2015 to 2017
$1.8M
Interruption of Signaling-Mediated Bacterial Persistent InfectionsR21AI105902 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI RAHME, LAURENCE G · 2013 to 2014
$478k
Function of MVFR in Pseudomonas Aeruginosa VirulenceR56AI063433 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI RAHME, LAURENCE G · 2012 to 2012
$475k
NIAID NIH HHS AI105902NIAID NIH HHS R21 AI105902NIAID NIH HHS R33 AI105902NIAID NIH HHS R56 AI063433NIAID NIH HHS R56AI063433
6 · The paper itself

Abstract

Bacterial persistence, which is observed in a broad range of microbial species, is the capacity of a bacterial cell subpopulation called "persisters" to tolerate exposure to normally lethal concentrations of bactericidal antibiotics. This ability, which is not due to antibiotic-resistant mutants, has been implicated in antibiotic treatment failures and may account for latent, chronic, and relapsing infections. Antibiotic tolerant/Persister (AT/P) cells have been notoriously difficult to study due to their low frequency and transient nature. This chapter describes the main methods used to isolate and study Pseudomonas aeruginosa AT/P cells and discusses new technologies that may ease research of P. aeruginosa persisters in the near future.

Indexed as

Anti-Bacterial AgentsColony Count, MicrobialDrug Resistance, BacterialMicrobial Sensitivity TestsMicrobial ViabilityMutationPseudomonas aeruginosaReproducibility of ResultsAnti-Bacterial Agents

Identifiers

PMID24818944
PMCPMC6538066

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.