Evidence map›Paper›PMID 24818873›Full record

ArticleJournal of materials science. Materials in medicine2014

An innovative approach to treating dental decay in children. A new anti-caries agent.

Andréa Gadelha Ribeiro Targino, Miguel Angel Pelagio Flores, Valdeci Elias dos Santos Junior, Fabiana de Godoy Bené Bezerra, Hilzeth de Luna Freire, André Galembeck, Aronita Rosenblatt

Registry-linked trialAbstract read
PubMed Publisher
In one paragraph

Article in Journal of materials science. Materials in medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04887389 (Cariostatic and Remineralizing Effects of Three Different Dental Varnishes), which is not on this map. Cited by 76 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
76citing papers in PubMed, 3 pooled it
5.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04887389 phase4completednot on this mapstarted 2021, after this paper: background citation

Cariostatic and Remineralizing Effects of Three Different Dental Varnishes (A Clinical Trial)

TypeinterventionalSponsorNisreen Ibrahim khanRan2021 to 2023Enrolled115ConditionsDental Caries in Children, Cariostatic Agent, Resistance, Dental Caries, Fluoride VarnishesArmsNano Silver Fluoride varnish, nano-hydroxyapatite varnish, sodium Fluoride Varnish
3 · Its place in the literature

Who cites it

76 citing papers in PubMed, 3 syntheses or guidelines pooled it, 169 citations in OpenAlex.

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  17. Antibacterial effect, antiadherence, and antiacidogenicity properties of a dental varnish containing silver nanoparticles: an in vitro study.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2025
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16 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Andréa Gadelha Ribeiro TarginoDepartment of Paediatric Dentistry, Faculty of Dentistry, University of Pernambuco, Av: Gal. Newton Cavalcanti nº 1650, Camaragibe, PE, CEP 54 753-020, Brazil, andreadoutorado@gmail.com.
Miguel Angel Pelagio Flores
Valdeci Elias dos Santos Junior
Fabiana de Godoy Bené Bezerra
Hilzeth de Luna Freire
André Galembeck
Aronita Rosenblatt
Universidade de Pernambuco · BRUniversidade Federal de Pernambuco · BRUniversidade Federal da Paraíba · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of this work is to evaluate the antimicrobial and cytotoxic activity of a formulation containing silver nanoparticles and chitosan, provisionally called nano silver fluoride (NSF), against Streptococcus mutans in comparison to chlorhexidine and silver diamine fluoride (SDF). The product was characterised by transmission electron microscopy and UV-Vis absorption spectroscopy. The minimum inhibition concentration (MIC) was evaluated by the spectrophotometric microdilution method and turbidity. The minimum bactericide concentration (MBC) was evaluated in brain heart infusion plates, and cytotoxicity was evaluated by haemolytic activity. The MIC and MBC for NSF were, respectively, 33.54 ± 14.52 and 50.32 µg/mL; for SDF were 33.33 ± 14.43 and 50.0 µg/mL, respectively; and for CHX were 3.3 ± 0.5 and 6 µg/mL, respectively. An ANOVA for MIC gave P = 0.032, and for MBC P = 0.035. The cytotoxic effect of NSF compared to SDF demonstrated a statistically significant difference in the MIC value (t test P < 0.05). The NSF formulation may be effective against S. mutans with much lower doses, may have lower toxicity than SDF, and may not stain teeth.

Indexed as

Anti-Bacterial AgentsChildDental CariesHumansMetal NanoparticlesMicrobial Sensitivity TestsMicroscopy, Electron, TransmissionSpectrophotometry, UltravioletStreptococcus mutansAnti-Bacterial Agents

Identifiers

PMID24818873
OpenAlexW1984098150

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.