ArticleAmerican journal of nephrology2014
α(E)-catenin regulates BMP-7 expression and migration in renal epithelial cells.
Article in American journal of nephrology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 10 citations in OpenAlex.
- Kidney Injury: Focus on Molecular Signaling Pathways.Current medicinal chemistry · 2024Review
- The impact of aging on epithelial barriers.Tissue barriers · 2017Review
- Twist2 Is Upregulated in Early Stages of Repair Following Acute Kidney Injury.International journal of molecular sciences · 2017Article
- Fascin2 regulates cisplatin-induced apoptosis in NRK-52E cells.Toxicology letters · 2017Article
- Loss of α(E)-catenin promotes Fas mediated apoptosis in tubular epithelial cells.Apoptosis : an international journal on programmed cell death · 2015Article
- The aging kidney: increased susceptibility to nephrotoxicity.International journal of molecular sciences · 2014Review
- Loss of α(E)-catenin potentiates cisplatin-induced nephrotoxicity via increasing apoptosis in renal tubular epithelial cells.Toxicological sciences : an official journal of the Society of Toxicology · 2014Article
- A role for the age-dependent loss of α(E)-catenin in regulation of N-cadherin expression and cell migration.Physiological reports · 2014Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThe aging kidney has a decreased ability to repair following injury. We have shown a loss in expression of α-catenin in the aging rat kidney and hypothesize that decreased α-catenin expression in tubular epithelial cells results in diminished repair capacity.
methodsIn an effort to elucidate alterations due to the loss of α-catenin, we generated NRK-52E cell lines with stable knockdown of α(E)-catenin.
resultsα(E)-catenin knockdown resulted in decreased wound repair due to alterations in cell migration. Analysis of gene expression in the α(E)-catenin knockdown cells demonstrated almost a complete loss of bone morphogenetic protein-7 (BMP-7) expression that was associated with decreased phospho-Smad1/5/8 staining. However, addition of exogenous BMP-7 increased phospho-Smad1/5/8, suggesting that the BMP-7 pathway remained intact in C2 cells. Given the potential role of BMP-7 in repair, we investigated its role in wound repair. Inhibition of BMP-7 decreased repair in non-targeted control cells; conversely, exogenous BMP-7 restored repair in α(E)-catenin knockdown cells to control levels.
conclusionsTaken together, the data suggests that the loss of α(E)-catenin expression and subsequent downregulation of BMP-7 is a mechanism underlying the altered migration of tubular epithelial cells that contributes to the inability of the aging kidney to repair following injury.
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