ReviewJournal of cellular biochemistry2014
Progenitor cells in proximal airway epithelial development and regeneration.
Review in Journal of cellular biochemistry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 43 citations in OpenAlex.
- Tuft cells shape airway remodeling by eliciting OXGR1- and SOX9-dependent stem cell programs.Nature communications · 2026Article
- Establishing an Ex Vivo Culture Model of Human Proximal Airway Tissue.Methods and protocols · 2025Article
- Basic Science Perspective on Engineering and Modeling the Large Airways.Advances in experimental medicine and biology · 2023Article
- Conditionally reprogrammed asthmatic bronchial epithelial cells express lowerAmerican journal of physiology. Lung cellular and molecular physiology · 2022Article
- Lung epithelium development and airway regeneration.Frontiers in cell and developmental biology · 2022Review
- Genome-Wide RNAi Screening Identifies Novel Pathways/Genes Involved in Oxidative Stress and Repurposable Drugs to Preserve Cystic Fibrosis Airway Epithelial Cell Integrity.Antioxidants (Basel, Switzerland) · 2021Article
- Lef-1 controls cell cycle progression in airway basal cells to regulate proliferation and differentiation.Stem cells (Dayton, Ohio) · 2021Article
- Pulmonary Sensory Receptors.Advances in anatomy, embryology, and cell biology · 2021Article
- Functional Exploration of the Pulmonary NEB ME.Advances in anatomy, embryology, and cell biology · 2021Article
- SCRINSHOT enables spatial mapping of cell states in tissue sections with single-cell resolution.PLoS biology · 2020Article
- Stem cells and lung regeneration.American journal of physiology. Cell physiology · 2020Review
- Paradigms that define lung epithelial progenitor cell fate in development and regeneration.Current stem cell reports · 2019Article
- Differential development of large-cell neuroendocrine or small-cell lung carcinoma upon inactivation of 4 tumor suppressor genes.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Heterogeneity of Pulmonary Stem Cells.Advances in experimental medicine and biology · 2019Review
- Selective activation and proliferation of a quiescent stem cell population in the neuroepithelial body microenvironment.Respiratory research · 2018Article
- Submucosal Gland Myoepithelial Cells Are Reserve Stem Cells That Can Regenerate Mouse Tracheal Epithelium.Cell stem cell · 2018Article
- Depletion of Airway Submucosal Glands and TP63American journal of respiratory and critical care medicine · 2018Article
- Buried myoepithelial stem cells as a reservoir for repairing the exposed airway epithelium.Stem cell investigation · 2018Article
- Multipotent Myoepithelial Progenitor Cells Are Born Early during Airway Submucosal Gland Development.American journal of respiratory cell and molecular biology · 2017Article
- Plasticity in the lung: making and breaking cell identity.Development (Cambridge, England) · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Multiple distinct epithelial domains are found throughout the airway that are distinguishable by location, structure, function, and cell-type composition. Several progenitor cell populations in the proximal airway have been identified to reside in confined microenvironmental niches including the submucosal glands (SMGs), which are embedded in the tracheal connective tissue between the surface epithelium and cartilage, and basal cells that reside within the surface airway epithelium (SAE). Current research suggests that regulatory pathways that coordinate development of the proximal airway and establishment of progenitor cell niches may overlap with pathways that control progenitor cell responses during airway regeneration following injury. SMGs have been shown to harbor epithelial progenitor cells, and this niche is dysregulated in diseases such as cystic fibrosis. However, mechanisms that regulate progenitor cell proliferation and maintenance within this glandular niche are not completely understood. Here we discuss glandular progenitor cells during development and regeneration of the proximal airway and compare properties of glandular progenitors to those of basal cell progenitors in the SAE. Further investigation into glandular progenitor cell control will provide a direction for interrogating therapeutic interventions to correct aberrant conditions affecting the SMGs in diseases such as cystic fibrosis, chronic bronchitis, and asthma.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.