Evidence map›Paper›PMID 24818173›Full record

ArticleJournal of surgery and science2013

Challenges in the Treatment of Triple Negative and HER2-Overexpressing Breast Cancer.

L Alexis Hoeferlin, Charles E Chalfant, Margaret A Park

Abstract read
In one paragraph

Article in Journal of surgery and science, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. COMMD3 loss drives invasive breast cancer growth by modulating copper homeostasis.Journal of experimental & clinical cancer research : CR · 2023
    Article
  6. Article
  7. Modulating the Activity of Androgen Receptor for Treating Breast Cancer.International journal of molecular sciences · 2022
    Review
  8. MicroRNA-1: Diverse role of a small player in multiple cancers.Seminars in cell & developmental biology · 2022
    Review
  9. Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Welcome to theJournal of surgery and science · 2013
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

L Alexis HoeferlinHunter Holmes McGuire VAMC, Dept. of Research and Development, Richmond VA, 23224 ( ), Virginia Commonwealth University Reanimation Engineering Science Center (VCURES), Richmond, Virginia 23298 ( ), Massey Cancer Center, Virginia Commonwealth University, Richmond VA, 23298 ( and Virginia Commonwealth University, Dept. of Biochemistry and Molecular Biology, Richmond VA, 23298 ( ).
Charles E ChalfantHunter Holmes McGuire VAMC, Dept. of Research and Development, Richmond VA, 23224 ( ), Virginia Commonwealth University Reanimation Engineering Science Center (VCURES), Richmond, Virginia 23298 ( ), Massey Cancer Center, Virginia Commonwealth University, Richmond VA, 23298 ( and Virginia Commonwealth University, Dept. of Biochemistry and Molecular Biology, Richmond VA, 23298 ( ).
Margaret A ParkHunter Holmes McGuire VAMC, Dept. of Research and Development, Richmond VA, 23224 ( ), Virginia Commonwealth University Reanimation Engineering Science Center (VCURES), Richmond, Virginia 23298 ( ), Massey Cancer Center, Virginia Commonwealth University, Richmond VA, 23298 ( and Virginia Commonwealth University, Dept. of Biochemistry and Molecular Biology, Richmond VA, 23298 ( ).

Funding

Center for Clinical and Translational ResearchUL1TR000058 · NCATS · VIRGINIA COMMONWEALTH UNIVERSITY · PI MOELLER, FREDERICK GERARD · 2012 to 2015
$12.5M
The Role of Ceramide Kinase in Eicosanoid SynthesisR01HL072925 · NHLBI · VIRGINIA COMMONWEALTH UNIVERSITY · PI CHALFANT, CHARLES E. · 2004 to 2012
$3.1M
Center for Clinical and Translational ResearchKL2TR000057 · NCATS · VIRGINIA COMMONWEALTH UNIVERSITY · PI MOELLER, FREDERICK GERARD · 2012 to 2014
$1.4M
Regulation of caspase 9 RNA splicing in NSCLC cancerR01CA154314 · NCI · VIRGINIA COMMONWEALTH UNIVERSITY · PI CHALFANT, CHARLES E. · 2011 to 2014
$1.2M
The role of RNA splicing in non-small cell lung cancerI01BX001792 · VA · VA VETERANS ADMINISTRATION HOSPITAL · PI CHALFANT, CHARLES E. · 2013 to 2024
–
BLRD VA I01 BX001792NCATS NIH HHS KL2 TR000057NCATS NIH HHS UL1 TR000058NCI NIH HHS R01 CA154314NHLBI NIH HHS R01 HL072925
6 · The paper itself

Abstract

While the 5-year survival rate of breast cancer is at an all-time high of 90%, this disease remains the second most common cause of cancer-related death, surpassed only by lung cancer in the US. The reasons for this discrepancy stem from cancer subtypes which become resistant to current therapies. These subtypes: "Triple negative" and ErbB2-overexpressing, are discussed in this review.

Indexed as

Breast CancerErbB2Estrogen receptorResistanceTriple negative

Identifiers

PMID24818173
PMCPMC4012677

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.