Evidence map›Paper›PMID 24818172›Full record

ArticleJournal of advances in dairy research2013

Coupling Mass Spectrometry-Based "Omic" Sciences with Bioguided Processing to Unravel Milk's Hidden Bioactivities.

David C Dallas, Hyeyoung Lee, Annabelle Le Parc, Juliana Maria Leite Nobrega de Moura Bell, Daniela Barile

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of advances in dairy research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.0field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

David C DallasDepartment of Food Science & Technology, University of California, One Shields Avenue, Davis, CA 95616, USA ; Foods for Health Institute, University of California, One Shields Avenue, Davis, CA 95616, USA.
Hyeyoung LeeDepartment of Food Science & Technology, University of California, One Shields Avenue, Davis, CA 95616, USA ; Foods for Health Institute, University of California, One Shields Avenue, Davis, CA 95616, USA.
Annabelle Le ParcDepartment of Food Science & Technology, University of California, One Shields Avenue, Davis, CA 95616, USA.
Juliana Maria Leite Nobrega de Moura BellDepartment of Food Science & Technology, University of California, One Shields Avenue, Davis, CA 95616, USA.
Daniela BarileDepartment of Food Science & Technology, University of California, One Shields Avenue, Davis, CA 95616, USA ; Foods for Health Institute, University of California, One Shields Avenue, Davis, CA 95616, USA.
University of California, Davis · US

Funding

Structures, Functions, & Genetic Diversity of Oligosaccharides in MilkR01HD061923 · NICHD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI LEBRILLA, CARLITO B · 2009 to 2013
$1.6M
Deciphering the function of naturally occurring peptides in human milkK99HD079561 · NICHD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI DALLAS, DAVID CHARLES · 2014 to 2015
$157k
NICHD NIH HHS K99 HD079561NICHD NIH HHS R01 HD061923
6 · The paper itself

Abstract

Many of milk's functional molecules could not be discovered until the right concordance of novel separation and analytical technologies were developed and applied. Many health-promoting components still await discovery due to technical challenges in their identification, isolation and testing. As new analytical technologies are assembled, new functional milk molecules will be discovered. Bovine milk is a source of a wide array of known bioactive compounds from a variety of molecular classes, including free glycans, lipids, glycolipids, peptides, proteins, glycoproteins, stem cells and microRNA. Because milk is such a complex mixture, when analyzed without fractionation or purification, many components mask the analytical signal of others, so some components cannot be detected. Modern analytics allow for the discovery and characterization of hundreds of novel milk compounds with high-resolution and high-accuracy. Liquid chromatography paired with electrospray ionization allows the separation of peptides, glycans and glycolipids for improved mass spectrometric detection. Target proteins and glycoproteins can now be purified from intact milk or other dairy streams by chromatography in order to better characterize these proteins for new bioactivities. The combination of advanced analytics with the new engineering capabilities will allow for high molecular resolution and separation techniques that can be scaled-up to semi-industrial and industrial scale for translation of lab-based discoveries. Bioguided analysis and design of dairy processing side streams will result in the transformation of waste into isolated functional ingredients to add value to dietary products.

Indexed as

Bioactive MoleculesBioguided ProcessingGlycanGlycolipidGlycoproteinMass SpectrometryMilkOligosaccharidePeptidePurification

Identifiers

PMID24818172
PMCPMC4012335
OpenAlexW2102982639

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.