Evidence map›Paper›PMID 24818168›Full record

ReviewJournal of immunology research2014

Some basic aspects of HLA-G biology.

Estibaliz Alegre, Roberta Rizzo, Daria Bortolotti, Sara Fernandez-Landázuri, Enrico Fainardi, Alvaro González

Registry-linked trialAbstract readReview
In one paragraph

Review in Journal of immunology research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03655925 (Plasma Levels of Human Leucocyte Antigen G in Patients With Chronic Heart Failure), which is not on this map. Cited by 46 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03655925 completednot on this mapstarted 2017, after this paper: background citation

Plasma Levels of Human Leucocyte Antigen G in Patients With Chronic Heart Failure

TypeobservationalSponsorPiera BoschettoRan2017 to 2019Enrolled40ConditionsChronic Heart FailureArmsplasmatic HLA-G
3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Insights into Reproductive Immunology and Placental Pathology.International journal of molecular sciences · 2024
    Article
  10. The Immune ModulationInternational journal of molecular sciences · 2024
    Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. HLA-G and the MHC Cusp Theory.Frontiers in immunology · 2022
    Review
  18. Immunogenetic Relationship ofInternational journal of general medicine · 2022
    Article
  19. Article
  20. Mesenchymal stem cell transfusion: Possible beneficial effects in COVID-19 patients.Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Estibaliz AlegreDepartment of Biochemistry, University Clinic of Navarra, Pamplona, Spain.ORCID 0000-0002-9053-3606
Roberta RizzoDepartment of Medical Sciences, Section of Microbiology and Medical Genetics, University of Ferrara, Ferrara, Italy.ORCID 0000-0001-9507-9126
Daria BortolottiDepartment of Medical Sciences, Section of Microbiology and Medical Genetics, University of Ferrara, Ferrara, Italy.ORCID 0000-0003-4496-9561
Sara Fernandez-LandázuriDepartment of Biochemistry, University Clinic of Navarra, Pamplona, Spain.
Enrico FainardiNeuroradiology Unit, Sant'Anna Hospital, Ferrara, Italy.ORCID 0000-0003-0477-724X
Alvaro GonzálezDepartment of Biochemistry, University Clinic of Navarra, Pamplona, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human leukocyte antigen-G (HLA-G) is a low polymorphic nonclassical HLA-I molecule restrictively expressed and with suppressive functions. HLA-G gene products are quite complex, with seven HLA-G isoforms, four membrane bound, and other three soluble isoforms that can suffer different posttranslational modifications or even complex formations. In addition, HLA-G has been described included in exosomes. In this review we will focus on HLA-G biochemistry with special emphasis to the mechanisms that regulate its expression and how the protein modifications affect the quantification in biological fluids.

Indexed as

Protein Processing, Post-TranslationalExosomesGene Expression RegulationHLA-G AntigensHumansMembrane ProteinsPromoter Regions, GeneticProtein IsoformsProtein MultimerizationProtein Structure, TertiaryReceptors, ImmunologicSolubilityUbiquitinationHLA-G AntigensMembrane ProteinsProtein IsoformsReceptors, Immunologic

Identifiers

PMID24818168
PMCPMC4000973

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.