ArticleBioMed research international2014
Arrabidaea chica hexanic extract induces mitochondrion damage and peptidase inhibition on Leishmania spp.
Article in BioMed research international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 43 citations in OpenAlex.
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- A Review of the Phytochemistry and Pharmacological Properties of the Genus Arrabidaea.Pharmaceuticals (Basel, Switzerland) · 2022Review
- Carajurin Induces Apoptosis inPharmaceuticals (Basel, Switzerland) · 2022Article
- Arrabidaea chica Verlot fractions reduce MIA-induced osteoarthritis progression in rat knees.Inflammopharmacology · 2021Article
- Antileishmanial Activity of Flavones-Rich Fraction FromFrontiers in pharmacology · 2021Article
- The Influence of Anthocyanidin Profile on Antileishmanial Activity ofMolecules (Basel, Switzerland) · 2020Article
- A Triazole Hybrid of Neolignans as a Potential Antileishmanial Agent by Triggering Mitochondrial Dysfunction.Molecules (Basel, Switzerland) · 2019Article
- Cytotoxicity and anti-Leishmania amazonensis activity of Citrus sinensis leaf extracts.Pharmaceutical biology · 2017Article
- Medicinal plants with promising antileishmanial activity in Iran: a systematic review and meta-analysis.Annals of medicine and surgery (2012) · 2017Review
- In vitro anti-leishmanial activity ofJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2016Article
- Apoptosis mediated leishmanicidal activity of Azadirachta indica bioactive fractions is accompanied by Th1 immunostimulatory potential and therapeutic cure in vivo.Parasites & vectors · 2015Article
- Plant-derived compounds in treatment of leishmaniasis.Iranian journal of veterinary research · 2015Review
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Currently available leishmaniasis treatments are limited due to severe side effects. Arrabidaea chica is a medicinal plant used in Brazil against several diseases. In this study, we investigated the effects of 5 fractions obtained from the crude hexanic extract of A. chica against Leishmania amazonensis and L. infantum, as well as on the interaction of these parasites with host cells. Promastigotes were treated with several concentrations of the fractions obtained from A. chica for determination of their minimum inhibitory concentration (MIC). In addition, the effect of the most active fraction (B2) on parasite's ultrastructure was analyzed by transmission electron microscopy. To evaluate the inhibitory activity of B2 fraction on Leishmania peptidases, parasites lysates were treated with the inhibitory and subinhibitory concentrations of the B2 fraction. The minimum inhibitory concentration of B2 fraction was 37.2 and 18.6 μg/mL for L. amazonensis and L. infantum, respectively. Important ultrastructural alterations as mitochondrial swelling with loss of matrix content and the presence of vesicles inside this organelle were observed in treated parasites. Moreover, B2 fraction was able to completely inhibit the peptidase activity of promastigotes at pH 5.5. The results presented here further support the use of A. chica as an interesting source of antileishmanial agents.
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