ArticleBioMed research international2014
Clinical and structural features of sperm head vacuoles in men included in the in vitro fertilization programme.
Article in BioMed research international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 19 citations in OpenAlex.
- Article
- Human Sperm Head Vacuoles Are Related to Nuclear-Envelope Invaginations.International journal of molecular sciences · 2023Article
- Aniline blue test for sperm protamination-a valuable add-on to the bull breeding soundness evaluation.Tropical animal health and production · 2023Article
- Viscous Cervical Environment-on-a-Chip for Selecting High-Quality Sperm from Human Semen.Biomedicines · 2021Article
- Combination of density gradient centrifugation and swim-up methods effectively decreases morphologically abnormal sperms.The Journal of reproduction and development · 2016Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The human sperm head vacuoles and their role in male infertility are still poorly understood. The aim of this study was to identify the clinical and ultrastructural features of human sperm head vacuoles in men included in the in vitro fertilization programme: men with normal (normozoospermia) and impaired sperm morphology (teratozoospermia). The sperm samples were observed under 6000-time magnification using motile sperm organelle morphology examination (MSOME). The proportion of sperm with head vacuoles was evaluated and related to the outcome of in vitro fertilization. The sperm of men with impaired sperm morphology was characterized by a higher proportion of sperm head vacuoles. The sperm head vacuoles were related to impaired semen quality (sperm concentration, motility, and morphology) but were not influenced by male factors (semen volume, height, age, weight, or body mass index). Moreover, sperm head vacuoles were related to impaired fertilization rate merely after classical in vitro fertilization (IVF), while there was no relation to pregnancy. In a subgroup of men, the sperm was fixed and observed by transmission electron microscopy (TEM). The ultrastructural study revealed that sperm head vacuoles are large nuclear indentations of various sizes and positions, packed with membranous material organized in membrane whorls (MW).
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