Evidence map›Paper›PMID 24818131›Full record

ArticleBioMed research international2014

Characterization of silk fibroin modified surface: a proteomic view of cellular response proteins induced by biomaterials.

Ming-Hui Yang, Shyng-Shiou Yuan, Tze-Wen Chung, Shiang-Bin Jong, Chi-Yu Lu, Wan-Chi Tsai, Wen-Cheng Chen, Po-Chiao Lin, Pei-Wen Chiang, Yu-Chang Tyan

Open access · hybridAbstract read
In one paragraph

Article in BioMed research international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 34 citations in OpenAlex.

  1. Article
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  3. A Review of Recent Developments in the Molecular Mechanisms of Bone Healing.International journal of molecular sciences · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Ming-Hui YangInstrument Technology Research Center, National Applied Research Laboratories, Hsinchu 300, Taiwan ; Department of Medical Research, Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung 807, Taiwan ; Translational Research Center, Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung 807, Taiwan.
Shyng-Shiou YuanDepartment of Medical Research, Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung 807, Taiwan ; Translational Research Center, Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung 807, Taiwan ; Department of Obstetrics and Gynecology, Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung 807, Taiwan ; School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
Tze-Wen ChungDepartment of Biomedical Engineering, National Yang-Ming University, Taipei 112, Taiwan.
Shiang-Bin JongDepartment of Medical Imaging and Radiological Sciences, Kaohsiung Medical University, Kaohsiung 807, Taiwan ; Department of Nuclear Medicine, Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung 807, Taiwan.
Chi-Yu LuDepartment of Biochemistry, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan ; National Sun Yat-Sen University-Kaohsiung Medical University Joint Research Center, Kaohsiung 804, Taiwan.
Wan-Chi TsaiDepartment of Medical Laboratory Science and Biotechnology, Kaohsiung Medical University, Kaohsiung 807, Taiwan ; Department of Laboratory Medicine, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan.
Wen-Cheng ChenDepartment of Fiber and Composite Materials, College of Engineering, Feng Chia University, Taichung 407, Taiwan.
Po-Chiao LinNational Sun Yat-Sen University-Kaohsiung Medical University Joint Research Center, Kaohsiung 804, Taiwan ; Department of Chemistry, National Sun Yat-Sen University, Kaohsiung 804, Taiwan.
Pei-Wen ChiangDepartment of Medical Imaging and Radiological Sciences, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
Yu-Chang TyanTranslational Research Center, Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung 807, Taiwan ; Department of Medical Imaging and Radiological Sciences, Kaohsiung Medical University, Kaohsiung 807, Taiwan ; National Sun Yat-Sen University-Kaohsiung Medical University Joint Research Center, Kaohsiung 804, Taiwan ; Center of Biomedical Engineering and System Biology, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
Kaohsiung Medical University Chung-Ho Memorial Hospital · TWNational Sun Yat-sen University · TWKaohsiung Medical University · TWFeng Chia University · TWNational Yang Ming Chiao Tung University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The purpose of this study was to develop the pathway of silk fibroin (SF) biopolymer surface induced cell membrane protein activation. Fibroblasts were used as an experimental model to evaluate the responses of cellular proteins induced by biopolymer material using a mass spectrometry-based profiling system. The surface was covered by multiwalled carbon nanotubes (CNTs) and SF to increase the surface area, enhance the adhesion of biopolymer, and promote the rate of cell proliferation. The amount of adhered fibroblasts on CNTs/SF electrodes of quartz crystal microbalance (QCM) greatly exceeded those on other surfaces. Moreover, analyzing differential protein expressions of adhered fibroblasts on the biopolymer surface by proteomic approaches indicated that CD44 may be a key protein. Through this study, utilization of mass spectrometry-based proteomics in evaluation of cell adhesion on biopolymer was proposed.

Indexed as

ProteomicsAnimalsBiocompatible MaterialsBromodeoxyuridineCell AdhesionCell ProliferationCell ShapeElectrodesFibroblastsFibroinsGene OntologyHyaluronan ReceptorsImmunohistochemistryMass SpectrometryMicroscopy, Atomic ForceNanotubes, CarbonBiocompatible MaterialsBromodeoxyuridineFibroinsHyaluronan ReceptorsNanotubes, CarbonProteins

Identifiers

PMID24818131
PMCPMC3982454
OpenAlexW2099142808

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.