Therapy-related B lymphoblastic leukemia with t(4;11)(q21;q23)/AF4-MLL in a patient with mantle cell lymphoma after recent aggressive chemotherapy: a unique case report.

Stephanie L Holdener, Lacey Harrington, Johnny Nguyen, Pedro Horna, Elizabeth Sagatys, Bijal Shah, Ling Zhang

Open access · greenAbstract readCase ReportsReview

In one paragraph

Review in International journal of clinical and experimental pathology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

0.8field-weighted citation impact, top 28% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

Transformation of Canine Lymphoma/Leukemia to More Aggressive Diseases: Anecdotes or Reality?Frontiers in veterinary science · 2015
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Stephanie L HoldenerDepartment of Pathology, University of South Florida Morsani College of Medicine Tampa, FL, USA.

Lacey HarringtonDepartment of Pathology, University of South Florida Morsani College of Medicine Tampa, FL, USA.

Johnny NguyenDepartment of Pathology, University of South Florida Morsani College of Medicine Tampa, FL, USA.

Pedro HornaDepartment of Hematopathology and Laboratory Medicine, H. Lee Moffitt Cancer Center and Research Institute Tampa, FL, USA.

Elizabeth SagatysDepartment of Hematopathology and Laboratory Medicine, H. Lee Moffitt Cancer Center and Research Institute Tampa, FL, USA.

Bijal ShahDepartment of Hematological Malignancies, H. Lee Moffitt Cancer Center and Research Institute Tampa, FL, USA.

Ling ZhangDepartment of Hematopathology and Laboratory Medicine, H. Lee Moffitt Cancer Center and Research Institute Tampa, FL, USA.

Moffitt Cancer Center · USUniversity of South Florida · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mantle cell lymphoma (MCL) is a mature B-cell lymphoma associated with the hallmark translocation t(11;14)(q13;32), which involves the cyclin D1 (CCND1) and immunoglobin heavy chain (IgH) genes. It may transform to a more aggressive blastoid or pleomorphic variant, with or without acquisition of chromosomal abnormalities. MCL could also present with a leukemic phase with marked lymphocytosis. A literature search did not reveal any prior reports of MCL transforming to or followed by a B-cell lymphoblastic leukemia (B-ALL).

Indexed as

Chromosomes, Human, Pair 11Chromosomes, Human, Pair 4Cyclin D1DNA-Binding ProteinsDrug-Related Side Effects and Adverse ReactionsDrug TherapyGene RearrangementHistone-Lysine N-MethyltransferaseHumansImmunoglobulin Heavy ChainsLymphoma, Mantle-CellMaleMiddle AgedMyeloid-Lymphoid Leukemia ProteinNuclear ProteinsPrecursor Cell Lymphoblastic Leukemia-LymphomaAFF1 protein, humanCyclin D1DNA-Binding ProteinsHistone-Lysine N-MethyltransferaseImmunoglobulin Heavy ChainsKMT2A protein, humanMyeloid-Lymphoid Leukemia ProteinNuclear ProteinsTranscriptional Elongation FactorslymphomaMantletherapytransformationvariant

Identifiers

PMID24817983

PMCPMC4014267

OpenAlexW128060473

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.