Evidence map›Paper›PMID 24817970›Full record

ArticleInternational journal of clinical and experimental pathology2014

Clinical relevance of tag single nucleotide polymorphisms within the CAT gene in patients with PTSD in the Chongqing Han population.

Zhao-Xia Duan, Wei Li, Jian-Yi Kang, Jie-Yuan Zhang, Kui-Jun Chen, Bing-Cang Li, Mei He, Jian-Min Wang

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in International journal of clinical and experimental pathology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Zhao-Xia DuanState Key Laboratory of Trauma, Burns and Combined Injury, Department 6 of Institute of Surgery Research, Daping Hospital, Third Military Medical University Chongqing 400042, China.
Wei LiDepartment of Neurology, Daping Hospital, Third Military Medical University Chongqing 400042, China.
Jian-Yi KangState Key Laboratory of Trauma, Burns and Combined Injury, Department 6 of Institute of Surgery Research, Daping Hospital, Third Military Medical University Chongqing 400042, China.
Jie-Yuan ZhangState Key Laboratory of Trauma, Burns and Combined Injury, Department 6 of Institute of Surgery Research, Daping Hospital, Third Military Medical University Chongqing 400042, China.
Kui-Jun ChenState Key Laboratory of Trauma, Burns and Combined Injury, Department 6 of Institute of Surgery Research, Daping Hospital, Third Military Medical University Chongqing 400042, China.
Bing-Cang LiState Key Laboratory of Trauma, Burns and Combined Injury, Department 6 of Institute of Surgery Research, Daping Hospital, Third Military Medical University Chongqing 400042, China.
Mei HeDepartment of Clinical Psychology, Southwest Hospital, Third Military Medical University Chongqing 400038, China.
Jian-Min WangState Key Laboratory of Trauma, Burns and Combined Injury, Department 6 of Institute of Surgery Research, Daping Hospital, Third Military Medical University Chongqing 400042, China.
Army Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFree radical-induced oxidative damage of the brain has been implicated in a number of psychiatric disorders, including post-traumatic stress disorder (PTSD). Catalase (CAT) is a major antioxidant enzyme and a number of polymorphisms in CAT have been shown to be associated with several diseases, including hypertension, diabetes mellitus, Alzheimer's disease, and vitiligo. The aim of this study was to evaluate the association of CAT gene polymorphisms with PTSD in a case-control study. MATERIALS AND

methodsA total of 460 unrelated adult Chinese Han adults, including 287 healthy volunteers and 173 patients with PTSD. Six tag single-nucleotide polymorphisms (tSNPs) were selected from the entire CAT gene through construction of haplotype bins, and they were genotyped using an improved multiplex ligation detection reaction (iMLDR) technique. Allelic frequencies and clinical characteristics were compared in two independent Chinese Han populations.

resultsSix tag SNPs were identified in the Chinese Han population and all were common SNPs. However, we could detect no evidence of genetic association between six tag SNPs in the CAT gene and PTSD in the Chinese Han population.

conclusionsThis result suggests that six tag SNPs of the CAT gene may not be associated with PTSD, and that CAT gene might not influence the development of PTSD in patients following exposure to a traumatic event, also may be the sample sizes too small to allow a meaningful test.

Indexed as

AdolescentAdultAsian PeopleCase-Control StudiesCatalaseChinaFemaleGene FrequencyGenetic Predisposition to DiseaseHaplotypesHumansMaleMiddle AgedPolymorphism, Single NucleotideStress Disorders, Post-TraumaticYoung AdultCatalasecase-control studyCatalasepost-traumatic stress disordertag single nucleotide polymorphisms

Identifiers

PMID24817970
PMCPMC4014254
OpenAlexW233302453

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.