ArticleInternational journal of clinical and experimental pathology2014
Dysregulation of microRNA biosynthesis enzyme Dicer plays an important role in gastric cancer progression.
Article in International journal of clinical and experimental pathology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 24 citations in OpenAlex.
- [DICER1 syndrome: clinical variety endocrine manifestations and features of diagnostics].Problemy endokrinologii · 2023Review
- Article
- Dicer Suppresses Hepatocellular Carcinoma via Interleukin-8 Pathway.Clinical Medicine Insights. Oncology · 2023Article
- Intermittent Hypoxia Increased the Expression of DBH and PNMT in Neuroblastoma Cells via MicroRNA-375-Mediated Mechanism.International journal of molecular sciences · 2022Article
- Intermittent Hypoxia Upregulates theInternational journal of molecular sciences · 2021Article
- Dicer increases the indication for trastuzumab treatment in gastric cancer patients via overexpression of human epidermal growth factor receptor 2.Scientific reports · 2021Article
- Dicer Enhances Bevacizumab-Related Inhibition of Hepatocellular Carcinoma via Blocking the Vascular Endothelial Growth Factor Pathway.Journal of hepatocellular carcinoma · 2021Article
- The Role of miR-181c in Mechanisms of Diabetes-Impaired Angiogenesis: An Emerging Therapeutic Target for Diabetic Vascular Complications.Frontiers in pharmacology · 2021Review
- Intermittent Hypoxia Up-RegulatesInternational journal of molecular sciences · 2019Article
- Association between SNPs in microRNA machinery genes and gastric cancer susceptibility, invasion, and metastasis in Chinese Han population.Oncotarget · 2017Article
- Up-regulation ofBiochemistry and biophysics reports · 2017Article
- MiR-153 regulates metastases of gastric cancer through Snail.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- Depletion of Dicer promotes epithelial ovarian cancer progression by elevating PDIA3 expression.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- Cytoplasmic Drosha Is Aberrant in Precancerous Lesions of Gastric Carcinoma and Its Loss Predicts Worse Outcome for Gastric Cancer Patients.Digestive diseases and sciences · 2016Article
- RASSF1A inhibits gastric cancer cell proliferation by miR-711- mediated downregulation of CDK4 expression.Oncotarget · 2016Article
- The Role of Mir-148a in Cancer.Journal of Cancer · 2016Review
- Low DICER1 expression is associated with poor clinical outcome in adrenocortical carcinoma.Oncotarget · 2015Article
- MicroRNAs: New Biomarkers for Diagnosis, Prognosis, Therapy Prediction and Therapeutic Tools for Breast Cancer.Theranostics · 2015Review
- The Role of microRNAs in Regulating Cancer Cell Response to Oxaliplatin-Containing Regimens.Technology in cancer research & treatmentReview
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimDicer is one of the most important components in microRNA biogenesis. Although studies have revealed the aberrantly expression of Dicer in types of cancer, the results were greatly controversial. Here we aimed to study the expression of Dicer in gastric cancer (GC) and further explored the possible roles of Dicer in cancer progression.
methodsThe alteration of Dicer-expression in GC and its clinical significance was retrospectively studied with immunohistochemical analyses on 377 cases of cancer tissues using tissue microarray (TMA). Dicer mRNA and protein levels were also examined in 8 paired of GC tissues and non-neoplastic surrounding gastric epithelium with real time RT-PCR and western blot.
resultsWe found that Dicer was reduced in GC tissues in both mRNA and protein levels. Moreover, down-regulation of Dicer was correlated highly with tumor differentiation (P<0.05) and lymph node invasion (P<0.05) in GC tissues, which suggested an essential role of Dicer in cancer invasion.
conclusionsConsidering that Dicer might be closely related to progression of GC, we proposed that Dicer might offer a promising target for prevention of metastatic progression in GC.
Indexed as
Identifiers
24817967PMC4014251W2199071672What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.