Evidence map›Paper›PMID 24817960›Full record

Observational studyInternational journal of clinical and experimental pathology2014

Characterization of the pathologic and endoscopic measurements of colorectal polyp sizes with a focus on sessile serrated adenoma and high-grade dysplasia.

Fan Li, Zheng Chen, Yu Yang, Xianghua Yi, Yunsheng Yang, Lanjing Zhang

Open access · greenAbstract readComparative StudyObservational Study
PubMed Full text at PMC
In one paragraph

Observational study in International journal of clinical and experimental pathology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 2 countries.

Fan LiDepartment of Gastroenterology and Hepatology, Chinese PLA General Hospital Beijing, China.
Zheng ChenDepartment of Chemical Process Development and Commercialization, Merck & Co. Rahway, NJ.
Yu YangDivision of Nephrology, Department of Medicine, University of Maryland School of Medicine Baltimore, MD.
Xianghua YiDepartment of Pathology, Tongji Hospital, Tongji University School of Medicine Shanghai, China.
Yunsheng YangDepartment of Gastroenterology and Hepatology, Chinese PLA General Hospital Beijing, China.
Lanjing ZhangDepartment of Pathology, University Medical Center of Princeton Plainsboro, NJ ; Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers University Piscataway, NJ ; Department of Pathology, Robert Wood Johnson Medical School, Rutgers University Piscataway, NJ ; Cancer Institute of New Jersey, Rutgers University Piscataway, NJ.
Chinese PLA General Hospital · CNMerck & Co., Inc., Rahway, NJ, USA (United States) · USRutgers, The State University of New Jersey · USTongji University · CNUniversity of Maryland, Baltimore · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe characteristics of pathologically measured (PMS) and endoscopically measured sizes (EMS) of the colorectal polyps (CRPs) is poorly understood, particularly in polypoid unremarkable mucosa (PUM), sessile serrated adenoma (SSA), and high-grade dysplasia (HGD).

methodsTo characterize the discordance and correlation between the PMS and EMS of CRPs including PUM, SSA, HGD, hyperplastic polyp (HP) and adenomas, we conducted this prospective observational study on the polyps collected between August 2012 and December 2013.

resultsPMS was significantly smaller than EMS in the 497 qualified CRPs regardless of the sites (left, transverse and right colorectum) or EMS (≥1 cm and <1 cm) subgroups. The PMS and EMS discordance was associated with a diagnosis of HP and adenoma (versus PUM, SSA or HGD), single fragment (versus multiple), 3 of the 8 endoscopists and PMS<1 cm (versus ≥1 cm). Despite a good correlation between EMS and PMS in the adenomas (ĸ=0.626, 95% confidence intervals [CI], 0.505-0.746) and a moderate correlation in the serrated polyps (SPs) including HP and SSA, (ĸ=0.424, 95% CI, 0.244-0.604), 40.4% (23/57) of the adenomas and 63.6% (21/33) of the SPs with EMS≥1 cm might warrant longer follow-up intervals since their PMS were <1 cm. The PMS and EMS had linear correlations except in CRPs with HGD or EMS≥1 cm.

conclusionsThe discordance between PMS and EMS is associated with the pathologic diagnosis, fragment number, endoscopists and PMS, and may lead to different follow-ups in a considerable portion of adenomas and SPs.

Indexed as

AdenomaAgedBiopsyColonic PolypsColorectal NeoplasmsEndoscopy, GastrointestinalFemaleHumansIntestinal MucosaLinear ModelsMaleMiddle AgedProspective StudiesRetrospective StudiescancercolonoscopymeasurementpathologyPolypsurveillance

Identifiers

PMID24817960
PMCPMC4014244
OpenAlexW88122664

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.