ArticleProceedings of SPIE--the International Society for Optical Engineering2013
The double-helix point spread function enables precise and accurate measurement of 3D single-molecule localization and orientation.
Article in Proceedings of SPIE--the International Society for Optical Engineering, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed.
- Enhanced supercritical angle localization microscopy through point spread function modeling.Biomedical optics express · 2025Article
- 3D Super-Resolution Imaging of PSD95 Reveals an Abundance of Diffuse Protein Supercomplexes in the Mouse Brain.ACS chemical neuroscience · 2025Article
- High-density volumetric super-resolution microscopy.Nature communications · 2024Article
- Quantifying nanoscopic alterations associated with mitochondrial dysfunction using three-dimensional single-molecule localization microscopy.Biomedical optics express · 2024Article
- MAxSIM: multi-angle-crossing structured illumination microscopy with height-controlled mirror for 3D topological mapping of live cells.Communications biology · 2023Article
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Abstract
Single-molecule-based super-resolution fluorescence microscopy has recently been developed to surpass the diffraction limit by roughly an order of magnitude. These methods depend on the ability to precisely and accurately measure the position of a single-molecule emitter, typically by fitting its emission pattern to a symmetric estimator (e.g. centroid or 2D Gaussian). However, single-molecule emission patterns are not isotropic, and depend highly on the orientation of the molecule's transition dipole moment, as well as its
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