Evidence map›Paper›PMID 24817764›Full record

ArticleEuropean polymer journal2013

Synthesis and characterization of novel elastomeric poly(D,L-lactide urethane) maleate composites for bone tissue engineering.

Angel E Mercado-Pagán, Yunqing Kang, Dai Fei Elmer Ker, Sangwon Park, Jeffrey Yao, Julius Bishop, Yunzhi Yang

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European polymer journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.9field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Treatment of critical-sized bone defects: clinical and tissue engineering perspectives.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2018
    Review
  5. Article
  6. Development and evaluation of elastomeric hollow fiber membranes as small diameter vascular graft substitutes.Materials science & engineering. C, Materials for biological applications · 2015
    Article
  7. Vascularization in bone tissue engineering constructs.Annals of biomedical engineering · 2015
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Angel E Mercado-PagánDepartment of Orthopedic Surgery, Stanford University, Stanford, CA, USA.
Yunqing KangDepartment of Orthopedic Surgery, Stanford University, Stanford, CA, USA.
Dai Fei Elmer KerDepartment of Orthopedic Surgery, Stanford University, Stanford, CA, USA.
Sangwon ParkDepartment of Prosthodontics, Dental Science Research Institute and BK21 Project, School of Dentistry, Chonnam National University, Gwangju, Republic of Korea.
Jeffrey YaoDepartment of Orthopedic Surgery, Stanford University, Stanford, CA, USA.
Julius BishopDepartment of Orthopedic Surgery, Stanford University, Stanford, CA, USA.
Yunzhi YangDepartment of Orthopedic Surgery, Stanford University, Stanford, CA, USA ; Department of Materials Science and Engineering, Stanford University, Stanford, CA, USA.
Stanford University · USChonnam National University · KR

Funding

Microengineered Osteons for Bone Tissue EngineeringR01AR057837 · NIAMS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI YANG, YUNZHI · 2010 to 2018
$5.1M
Engineering Vascularized Bone Tissues By Microfabrication And ScaffoldingR01DE021468 · NIDCR · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI YANG, YUNZHI · 2011 to 2014
$1.8M
NIAMS NIH HHS R01 AR057837NIDCR NIH HHS R01 DE021468
6 · The paper itself

Abstract

Here, we report the synthesis and characterization of a novel 4-arm poly(lactic acid urethane)-maleate (4PLAUMA) elastomer and its composites with nano-hydroxyapatite (nHA) as potential weight-bearing composite. The 4PLAUMA/nHA ratios of the composites were 1:3, 2:5, 1:2 and 1:1. FTIR and NMR characterization showed urethane and maleate units integrated into the PLA matrix. Energy dispersion and Auger electron spectroscopy confirmed homogeneous distribution of nHA in the polymer matrix. Maximum moduli and strength of the composites of 4PLAUMA/nHA, respectively, are 1973.31 ± 298.53 MPa and 78.10 ± 3.82 MPa for compression, 3630.46 ± 528.32 MPa and 6.23 ± 1.44 MPa for tension, 1810.42 ± 86.10 MPa and 13.00 ± 0.72 for bending, and 282.46 ± 24.91 MPa and 5.20 ± 0.85 MPa for torsion. The maximum tensile strains of the polymer and composites are in the range of 5% to 93%, and their maximum torsional strains vary from 0.26 to 0.90. The composites exhibited very slow degradation rates in aqueous solution, from approximately 50% mass remaining for the pure polymer to 75% mass remaining for composites with high nHA contents, after a period of 8 weeks. Increase in ceramic content increased mechanical properties, but decreased maximum strain, degradation rate, and swelling of the composites. Human bone marrow stem cells and human endothelial cells adhered and proliferated on 4PLAUMA films and degradation products of the composites showed little-to-no toxicity. These results demonstrate that novel 4-arm poly(lactic acid urethane)-maleate (4PLAUMA) elastomer and its nHA composites may have potential applications in regenerative medicine.

Indexed as

bone void fillersceramic compositeshydroxyapatite compositesload-bearing fillersPolyester urethanesurethane composites

Identifiers

PMID24817764
PMCPMC4012890
OpenAlexW2060529584

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.