ArticleActa crystallographica. Section F, Structural biology communications2014
Applications of the second virial coefficient: protein crystallization and solubility.
Article in Acta crystallographica. Section F, Structural biology communications, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed.
- The Effects of Electric Fields on Protein Phase Behavior and Protein Crystallization Kinetics.The journal of physical chemistry letters · 2024Article
- Probing interactions of therapeutic antibodies with serum via second virial coefficient measurements.Biophysical journal · 2021Article
- Improved adsorption reactions, kinetics and stability for model and therapeutic proteins immobilised on affinity resins.Adsorption : journal of the International Adsorption Society · 2019Article
- In silico prediction of monovalent and chimeric tetravalent vaccines for prevention and treatment of dengue fever.Journal of biomedical research · 2017Article
- High Throughput Prediction Approach for Monoclonal Antibody Aggregation at High Concentration.Pharmaceutical research · 2017Article
- Applications of the second virial coefficient: protein crystallization and solubility. Corrigendum.Acta crystallographica. Section F, Structural biology communications · 2016Article
- Lessons from ten years of crystallization experiments at the SGC.Acta crystallographica. Section D, Structural biology · 2016Article
- Origin and use of crystallization phase diagrams.Acta crystallographica. Section F, Structural biology communications · 2015Article
- Crystallization of lysozyme with (R)-, (S)- and (RS)-2-methyl-2,4-pentanediol.Acta crystallographica. Section D, Biological crystallography · 2015Article
- Membrane proteins, detergents and crystals: what is the state of the art?Acta crystallographica. Section F, Structural biology communications · 2014Review
- Protein solubilization: a novel approach.Journal of chromatography. B, Analytical technologies in the biomedical and life sciences · 2014Article
- Identifying, studying and making good use of macromolecular crystals.Acta crystallographica. Section F, Structural biology communications · 2014Article
Corrections and comments
- Erratum issued
Authors and funding
2 authors.
Funding
Abstract
This article begins by highlighting some of the ground-based studies emanating from NASA's Microgravity Protein Crystal Growth (PCG) program. This is followed by a more detailed discussion of the history of and the progress made in one of the NASA-funded PCG investigations involving the use of measured second virial coefficients (B values) as a diagnostic indicator of solution conditions conducive to protein crystallization. A second application of measured B values involves the determination of solution conditions that improve or maximize the solubility of aqueous and membrane proteins. These two important applications have led to several technological improvements that simplify the experimental expertise required, enable the measurement of membrane proteins and improve the diagnostic capability and measurement throughput.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.