ArticleMolecular biology and evolution2014
Inter- and intraspecies phylogenetic analyses reveal extensive X-Y gene conversion in the evolution of gametologous sequences of human sex chromosomes.
Article in Molecular biology and evolution, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 32 citations in OpenAlex.
- Evolutionary divergence between homologous X-Y chromosome genes shapes sex-biased biology.Nature ecology & evolution · 2025Article
- Sex Chromosome Evolution: Hallmarks and Question Marks.Molecular biology and evolution · 2024Review
- Sequence Transpositions Restore Genes on the Highly Degenerated W Chromosomes of Songbirds.Genes · 2020Article
- Review
- Article
- Exchange of genetic information between therian X and Y chromosome gametologs in old evolutionary strata.Ecology and evolution · 2017Article
- Human Y-chromosome variation in the genome-sequencing era.Nature reviews. Genetics · 2017Review
- The Y chromosomes of the great apes.Human genetics · 2017Review
- Y chromosome palindromes and gene conversion.Human genetics · 2017Review
- Patterns of Inter-Chromosomal Gene Conversion on the Male-Specific Region of the Human Y Chromosome.Frontiers in genetics · 2017Review
- Evidence of extensive non-allelic gene conversion among LTR elements in the human genome.Scientific reports · 2016Article
- Genetic Diversity on the Human X Chromosome Does Not Support a Strict Pseudoautosomal Boundary.Genetics · 2016Article
- Chromosome Y genetic variants: impact in animal models and on human disease.Physiological genomics · 2015Review
- Genome-Wide Search Identifies 1.9 Mb from the Polar Bear Y Chromosome for Evolutionary Analyses.Genome biology and evolution · 2015Article
- The Y-chromosome tree bursts into leaf: 13,000 high-confidence SNPs covering the majority of known clades.Molecular biology and evolution · 2015Article
- Article
- Independent stratum formation on the avian sex chromosomes reveals inter-chromosomal gene conversion and predominance of purifying selection on the W chromosome.Evolution; international journal of organic evolution · 2014Article
- Isolation of Nucleated Red Blood Cells With Intact Genomic DNA From Cord Blood by Applying G&T-Seq.Reproductive medicine and biologyArticle
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It has long been believed that the male-specific region of the human Y chromosome (MSY) is genetically independent from the X chromosome. This idea has been recently dismissed due to the discovery that X-Y gametologous gene conversion may occur. However, the pervasiveness of this molecular process in the evolution of sex chromosomes has yet to be exhaustively analyzed. In this study, we explored how pervasive X-Y gene conversion has been during the evolution of the youngest stratum of the human sex chromosomes. By comparing about 0.5 Mb of human-chimpanzee gametologous sequences, we identified 19 regions in which extensive gene conversion has occurred. From our analysis, two major features of these emerged: 1) Several of them are evolutionarily conserved between the two species and 2) almost all of the 19 hotspots overlap with regions where X-Y crossing-over has been previously reported to be involved in sex reversal. Furthermore, in order to explore the dynamics of X-Y gametologous conversion in recent human evolution, we resequenced these 19 hotspots in 68 widely divergent Y haplogroups and used publicly available single nucleotide polymorphism data for the X chromosome. We found that at least ten hotspots are still active in humans. Hence, the results of the interspecific analysis are consistent with the hypothesis of widespread reticulate evolution within gametologous sequences in the differentiation of hominini sex chromosomes. In turn, intraspecific analysis demonstrates that X-Y gene conversion may modulate human sex-chromosome-sequence evolution to a greater extent than previously thought.
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