ArticleInternational journal for numerical methods in biomedical engineering2014
Mathematical modelling of the pathogenesis of multiple myeloma-induced bone disease.
Article in International journal for numerical methods in biomedical engineering, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- The bone ecosystem facilitates multiple myeloma relapse and the evolution of heterogeneous drug resistant disease.Nature communications · 2024Article
- Article
- Mathematical modelling of the role of GADD45β in the pathogenesis of multiple myeloma.Royal Society open science · 2020Article
- Modeling the Human Bone-Tumor Niche: Reducing and Replacing the Need for Animal Data.JBMR plus · 2020Review
- Toward a Mathematical Modeling of Diseases' Impact on Bone Remodeling: Technical Review.Frontiers in bioengineering and biotechnology · 2020Review
- Modeling the Effects of Multiple Myeloma on Kidney Function.Scientific reports · 2019Article
- A Retrospective Analysis: A Novel Index Predicts Survival and Risk-Stratification for Bone Destruction in 419 Newly Diagnosed Multiple Myelomas.OncoTargets and therapy · 2019Article
- Considerations for Adapting Pre-existing Mechanistic Quantitative Systems Pharmacology Models for New Research Contexts.Frontiers in pharmacology · 2019Article
- Predictive computational modeling to define effective treatment strategies for bone metastatic prostate cancer.Scientific reports · 2016Article
- A virtual approach to evaluate therapies for management of multiple myeloma induced bone disease.International journal for numerical methods in biomedical engineering · 2016Article
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Authors and funding
4 authors.
Funding
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Abstract
Multiple myeloma (MM) is the second most common haematological malignancy and results in destructive bone lesions. The interaction between MM cells and the bone microenvironment plays an important role in the development of the tumour cells and MM-induced bone disease and forms a 'vicious cycle' of tumour development and bone destruction, intensified by suppression of osteoblast activity and promotion of osteoclast activity. In this paper, a mathematical model is proposed to simulate how the interaction between MM cells and the bone microenvironment facilitates the development of the tumour cells and the resultant bone destruction. It includes both the roles of inhibited osteoblast activity and stimulated osteoclast activity. The model is able to mimic the temporal variation of bone cell concentrations and resultant bone volume after the invasion and then removal of the tumour cells and explains why MM-induced bone lesions rarely heal even after the complete removal of MM cells. The behaviour of the model compares well with published experimental data. The model serves as a first step to understand the development of MM-induced bone disease and could be applied further to evaluate the current therapies against MM-induced bone disease and even suggests new potential therapeutic targets.
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