ArticlePloS one2014
Antifungal activity of naphthoquinoidal compounds in vitro against fluconazole-resistant strains of different Candida species: a special emphasis on mechanisms of action on Candida tropicalis.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 63 citations in OpenAlex.
- Preventive action of ketamine alone and in combination with antifungals on Candida biofilm formation in catheters.International microbiology : the official journal of the Spanish Society for Microbiology · 2026Article
- Duloxetine repositioning: Investigation of antifungal and antibiofilm activity against fluconazole-sensitive and resistant Candida Spp. strains.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2026Article
- Antifungal Activity and Possible Mechanism of Action of the Zn (II) Complex With a Schiff Base Against Fluconazole-Resistant Strains of Candida spp. and Cryptococcus neoformans.Chemistry & biodiversity · 2026Article
- Characterization and Antifungal Activity of Essential oil of Cymbopogon citratus: Special Emphasis on Preliminary Fungicidal Mechanisms against Candida auris and Cryptococcus neoformans.Current microbiology · 2026Article
- Analysis of the anti-Candida activity of tricyclic antidepressants in association with amphotericin B and their antifungal mechanisms.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024Article
- Antifungal activity of tannic acid against Candida spp. and its mechanism of action.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024Article
- Mangiferin potentiates the activity of antifungal agents against fluconazole-resistantFuture microbiology · 2024Article
- Anticandidal activity ofFuture microbiology · 2024Article
- Redox and Nucleophilic Reactions of Naphthoquinones with Small Thiols and Their Effects on Oxidization of HInternational journal of molecular sciences · 2023Article
- The Antimicrobial Peptide MK58911-NHAntimicrobial agents and chemotherapy · 2021Article
- Piperidine based 1,2,3-triazolylacetamide derivatives induce cell cycle arrest and apoptotic cell death inJournal of advanced research · 2021Article
- Phytogenic Fabrication of Ag-Fe Bimetallic Nanoparticles for Cell Cycle Arrest and Apoptosis Signaling Pathways inAntioxidants (Basel, Switzerland) · 2021Article
- Facile Bio-Fabrication of Ag-Cu-Co Trimetallic Nanoparticles and Its Fungicidal Activity againstJournal of fungi (Basel, Switzerland) · 2021Article
- Article
- Azole Based Acetohydrazide Derivatives of Cinnamaldehyde Target and KillACS medicinal chemistry letters · 2020Article
- Antifungal and Antivirulence Activities of Hydroalcoholic Extract and Fractions ofPathogens (Basel, Switzerland) · 2020Article
- Synthetic Naphthofuranquinone Derivatives Are Effective in Eliminating Drug-ResistantFrontiers in microbiology · 2020Article
- Naphthoquinone Derivatives as Scaffold to Develop New Drugs for Tuberculosis Treatment.Frontiers in microbiology · 2018Article
- The Role of UPC2 Gene in Azole-Resistant Candida tropicalis.Mycopathologia · 2016Article
- Analysis of the genetic diversity of Candida isolates obtained from diabetic patients and kidney transplant recipients.Memorias do Instituto Oswaldo Cruz · 2016Article
Corrections and comments
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Authors and funding
17 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In recent decades, the incidence of candidemia in tertiary hospitals worldwide has substantially increased. These infections are a major cause of morbidity and mortality; in addition, they prolong hospital stays and raise the costs associated with treatment. Studies have reported a significant increase in infections by non-albicans Candida species, especially C. tropicalis. The number of antifungal drugs on the market is small in comparison to the number of antibacterial agents available. The limited number of treatment options, coupled with the increasing frequency of cross-resistance, makes it necessary to develop new therapeutic strategies. The objective of this study was to evaluate and compare the antifungal activities of three semisynthetic naphthofuranquinone molecules against fluconazole-resistant Candida spp. strains. These results allowed to us to evaluate the antifungal effects of three naphthofuranquinones on fluconazole-resistant C. tropicalis. The toxicity of these compounds was manifested as increased intracellular ROS, which resulted in membrane damage and changes in cell size/granularity, mitochondrial membrane depolarization, and DNA damage (including oxidation and strand breakage). In conclusion, the tested naphthofuranquinones (compounds 1-3) exhibited in vitro cytotoxicity against fluconazole-resistant Candida spp. strains.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.