ArticlePloS one2014
Electrical wave propagation in an anisotropic model of the left ventricle based on analytical description of cardiac architecture.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 37 citations in OpenAlex.
- Rapid prediction of cardiac activation in the left ventricle with geometric deep learning: a step towards cardiac resynchronization therapy planning.NPJ digital medicine · 2026Article
- Algorithmic Generation of Parameterized Geometric Models of the Aortic Valve and Left Ventricle.Sensors (Basel, Switzerland) · 2024Article
- Mechanistic assessment and ablation of left ventricular assist device related ventricular tachycardia in patients with severe heart failure.Frontiers in physiology · 2023Article
- Parameter variations in personalized electrophysiological models of human heart ventricles.PloS one · 2021Article
- Conduction in the Heart Wall: Helicoidal Fibers Minimize Diffusion Bias.Scientific reports · 2018Article
- Gaussian Process Regressions for Inverse Problems and Parameter Searches in Models of Ventricular Mechanics.Frontiers in physiology · 2018Article
- Mechano-electric heterogeneity of the myocardium as a paradigm of its function.Progress in biophysics and molecular biology · 2016Review
- A model model: a commentary on DiFrancesco and Noble (1985) 'A model of cardiac electrical activity incorporating ionic pumps and concentration changes'.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Review
- Drift of Scroll Wave Filaments in an Anisotropic Model of the Left Ventricle of the Human Heart.BioMed research international · 2015Article
Corrections and comments
- Erratum issued
Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We develop a numerical approach based on our recent analytical model of fiber structure in the left ventricle of the human heart. A special curvilinear coordinate system is proposed to analytically include realistic ventricular shape and myofiber directions. With this anatomical model, electrophysiological simulations can be performed on a rectangular coordinate grid. We apply our method to study the effect of fiber rotation and electrical anisotropy of cardiac tissue (i.e., the ratio of the conductivity coefficients along and across the myocardial fibers) on wave propagation using the ten Tusscher-Panfilov (2006) ionic model for human ventricular cells. We show that fiber rotation increases the speed of cardiac activation and attenuates the effects of anisotropy. Our results show that the fiber rotation in the heart is an important factor underlying cardiac excitation. We also study scroll wave dynamics in our model and show the drift of a scroll wave filament whose velocity depends non-monotonically on the fiber rotation angle; the period of scroll wave rotation decreases with an increase of the fiber rotation angle; an increase in anisotropy may cause the breakup of a scroll wave, similar to the mother rotor mechanism of ventricular fibrillation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.