Trial reportKnee surgery, sports traumatology, arthroscopy : official journal of the ESSKA2014
Matrix-induced autologous chondrocyte implantation (MACI) for chondral defects in the patellofemoral joint.
Trial report in Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07641868 (Management of Focal Cartilage Lesions of the Knee), which is not on this map. Cited by 35 papers, 7 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Management of Focal Cartilage Lesions of the Knee: The Benefits of an Autograft Procedure
Who cites it
35 citing papers in PubMed, 7 syntheses or guidelines pooled it.
- The use of autologous chondrocyte transplantation for the treatment of osteoarthritis: a systematic review of clinical trials.Cell and tissue banking · 2024Pooled it
- Prognostic factors for the management of chondral defects of the knee and ankle joint: a systematic review.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2023Pooled it
- Surgical strategies for chondral defects of the patellofemoral joint: a systematic review.Journal of orthopaedic surgery and research · 2022Pooled it
- Matrix-induced autologous chondrocyte implantation (mACI) versus autologous matrix-induced chondrogenesis (AMIC) for chondral defects of the knee: a systematic review.British medical bulletin · 2022Pooled it
- Pooled it
- Typical MRI-pattern suggests peak maturation of the ACI graft 2 years after third-generation ACI: a systematic review.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2021Pooled it
- Return to sport after the surgical management of articular cartilage lesions in the knee: a meta-analysis.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2017Pooled it
- Cartilage restoration procedures in patellofemoral stabilization.Annals of joint · 2026Review
- Chondroplasty for isolated medial patellar facet cartilage lesions demonstrates no difference in clinical outcomes compared to a matched cohort of patients without patellofemoral chondral pathology in the setting of medial patellofemoral ligament reconstruction.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2025Article
- Review
- Patellofemoral Joint Chondral Defects Treated With Third-Generation Matrix-Induced Autologous Chondrocyte Implantation on Porcine Collagen Membrane: Minimum 2-Year Follow-up.Orthopaedic journal of sports medicine · 2025Article
- Clinical and Radiological Outcomes at ≥10-Year Follow-up After Matrix-induced Autologous Chondrocyte Implantation in the Patellofemoral Joint.The American journal of sports medicine · 2024Article
- Treatment of cartilage defects in the patellofemoral joint with matrix-associated autologous chondrocyte implantation effectively improves pain, function, and radiological outcomes after 5-7 years.Archives of orthopaedic and trauma surgery · 2024Article
- Cartilage Biopsy for Autologous Cell-Based Repair of the Knee in the Wide-Awake Setting Using Needle Arthroscopy.Arthroscopy techniques · 2023Article
- Fixation of the Membrane during Matrix-Induced Autologous Chondrocyte Implantation in the Knee: A Systematic Review.Life (Basel, Switzerland) · 2022Review
- Excellent clinical and radiological outcomes after both open flake refixation and autologous chondrocyte implantation following acute patella dislocation and concomitant flake fractures.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2022Article
- Fibrin glue does not assist migration and proliferation of chondrocytes in collagenic membranes: an in vitro study.Journal of orthopaedic surgery and research · 2022Article
- Good healing potential of patellar chondral defects after all-arthroscopic autologous chondrocyte implantation with spheroids: a second-look arthroscopic assessment.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2022Article
- Accurate Reporting of Concomitant Procedures Is Highly Variable in Studies Investigating Knee Cartilage Restoration.Cartilage · 2021Article
- Effect of the defect localization and size on the success of third-generation autologous chondrocyte implantation in the knee joint.International orthopaedics · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeBoth autologous chondrocyte implantation (ACI) and tibial tubercle transfer (TTT) have been used to treat chondral defects in the patellofemoral joint resulting in clinical improvement. Our study investigates the magnetic resonance imaging (MRI) appearance of the matrix-induced autologous chondrocyte implantation (MACI) graft at 5-year follow-up to determine if it provides a durable treatment option in patients with an average age of 42 (standard deviation 11.6).
methodsTwenty-three patients were available for follow-up. Nine patients required realignment of the extensor mechanism with lateral release and TTT. The MRI magnetic resonance observation of cartilage repair tissue (MOCART) scoring system was used to assess the graft status. Clinical outcomes were assessed at these time periods.
resultsThe mean weighted MOCART composite score improved from 2.87 at 3 months to 3.39 at 5 years, indicating an intact appearance in most grafts. Graft height measured >50% of the adjacent native cartilage in 82% of patients. Clinical improvement assessed by the Knee Injury and Osteoarthritis Outcome Score, SF-36 (PCS) and the 6-minute walk test was demonstrated between pre-operative scores and final 5-year follow-up. 91% of patients would undergo MACI again. Correlation between MOCART and clinical scores were low in MACI to the patellofemoral joint. No significant difference was found in outcome between those that required realignment surgery compared with those that did not.
conclusionPatellofemoral MACI provides a durable graft on MRI assessment at 5 years with resultant clinical improvement. Further work is needed to determine which defect locations may benefit most from this procedure. LEVEL OF EVIDENCE: IV.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.