Evidence map›Paper›PMID 24817135›Full record

Trial reportPloS one2014

Impact of mental and physical stress on blood pressure and pulse pressure under normobaric versus hypoxic conditions.

Michael Trapp, Eva-Maria Trapp, Josef W Egger, Wolfgang Domej, Giuseppe Schillaci, Alexander Avian, Peter M Rohrer, Nina Hörlesberger, Dieter Magometschnigg, Mila Cervar-Zivkovic and 3 more

Open access · goldAbstract readClinical Trial
In one paragraph

Trial report in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.

  1. Pooled it
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  3. Higher VOScientific reports · 2021
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  7. Biomarkers and Detection Platforms for Human Health and Performance Monitoring: A Review.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 3 countries.

Michael TrappResearch Unit of Behavioural Medicine, Health Psychology and Empirical Psychosomatics, Department of Medical Psychology and Psychotherapy, Medical University of Graz, Graz, Austria.
Eva-Maria TrappResearch Unit of Behavioural Medicine, Health Psychology and Empirical Psychosomatics, Department of Medical Psychology and Psychotherapy, Medical University of Graz, Graz, Austria; University Clinic of Psychiatry. Medical University of Graz, Graz, Austria.
Josef W EggerResearch Unit of Behavioural Medicine, Health Psychology and Empirical Psychosomatics, Department of Medical Psychology and Psychotherapy, Medical University of Graz, Graz, Austria.
Wolfgang DomejDepartment of Pneumology, Medical University of Graz, Graz, Austria.
Giuseppe SchillaciDepartment of Medicine, University of Perugia and Terni University Hospital, Terni, Italy.
Alexander AvianInstitute for Medical Informatics, Statistics and Documentation, Medical University of Graz, Graz, Austria.
Peter M RohrerResearch Unit of Behavioural Medicine, Health Psychology and Empirical Psychosomatics, Department of Medical Psychology and Psychotherapy, Medical University of Graz, Graz, Austria.
Nina HörlesbergerResearch Unit of Behavioural Medicine, Health Psychology and Empirical Psychosomatics, Department of Medical Psychology and Psychotherapy, Medical University of Graz, Graz, Austria.
Dieter MagometschniggInstitute for Hypertension, Vienna, Austria.
Mila Cervar-ZivkovicDepartment of Obstetrics and Gynecology, Medical University of Graz, Graz, Austria.
Peter KomerickiDepartment of Dermatology, Medical University of Graz, Graz, Austria.
Rosemarie VelikCTR Carinthian Tech Research, Villach/St. Magdalen, Austria.
Johannes BaulmannUKSH Universitätsklinikum Schleswig-Holstein, Campus Lübeck, Lübeck, Germany.
Medical University of Graz · ATCarinthian Tech Research · ATUniversity Hospital Schleswig-Holstein · DEUniversity of Perugia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveHypobaric hypoxia, physical and psychosocial stress may influence key cardiovascular parameters including blood pressure (BP) and pulse pressure (PP). We investigated the effects of mild hypobaric hypoxia exposure on BP and PP reactivity to mental and physical stress and to passive elevation by cable car.

methods36 healthy volunteers participated in a defined test procedure consisting of a period of rest 1, mental stress task (KLT-R), period of rest 2, combined mental (KLT-R) and physical task (bicycle ergometry) and a last period of rest both at Graz, Austria (353 m asl) and at the top station Dachstein (2700 m asl). Beat-to-beat heart rate and BP were analysed both during the test procedures at Graz and at Dachstein and during passive 1000 m elevation by cable car (from 1702 m to 2700 m).

resultsA significant interaction of kind of stress (mental vs. combined mental and physical) and study location (Graz vs. Dachstein) was found in the systolic BP (p = .007) and PP (p = .002) changes indicating that during the combined mental and physical stress task sBP was significantly higher under hypoxic conditions whereas sBP and PP were similar during mental stress both under normobaric normoxia (Graz) and under hypobaric hypoxia (Dachstein). During the passive ascent in cable car less trivialization (psychological coping strategy) was associated with an increase in PP (p = .004).

conclusionOur data show that combined mental and physical stress causes a significant higher raise in sBP and PP under hypoxic conditions whereas isolated mental stress did not affect sBP and PP under hypoxic conditions. PP-reaction to ascent in healthy subjects is not uniform. BP reactions to ascent that represents an accumulation of physical (mild hypobaric hypoxia) and psychological stressors depend on predetermined psychological traits (stress coping strategies). Thus divergent cardiovascular reactions can be explained by applying the multidimensional aspects of the biopsychosocial concept.

Indexed as

AdultBlood PressureCardiovascular Physiological PhenomenaCross-Over StudiesExercise TestFemaleHeart RateHumansHypoxiaLogistic ModelsMaleMultivariate AnalysisPulseStress, PsychologicalSurveys and QuestionnairesYoung Adult

Identifiers

PMID24817135
PMCPMC4015896
OpenAlexW2024288376

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.