ArticleSurgery today2015
Prognostic significance of the preoperative serum C-reactive protein level in patients with stage IV colorectal cancer.
Article in Surgery today, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Abundant intratumoral fibrosis prevents lymphocyte infiltration into peritoneal metastases of colorectal cancer.PloS one · 2021Trial
- Inflammatory indexes as predictors of prognosis and bevacizumab efficacy in patients with metastatic colorectal cancer.Oncotarget · 2016Trial
- The prognostic importance of the global immune-nutrition-information index (GINI) in patients with Ras wild type metastatic colorectal cancer.Scientific reports · 2025Article
- Integrated Early CRP Kinetics and Plasma EBV DNA Clearance as Prognostic Biomarkers in De Novo Metastatic Nasopharyngeal Carcinoma Treated with First-Line Chemoimmunotherapy.Journal of inflammation research · 2025Article
- The combined detection of hematological indicators is used for the differential diagnosis of colorectal cancer and benign-colorectal lesions.Cancer biomarkers : section A of Disease markers · 2024Article
- Inflammatory indices as prognostic markers in metastatic colorectal cancer patients treated with chemotherapy plus Bevacizumab.Therapeutic advances in medical oncology · 2023Article
- Effect of CRP and Kinetics of CRP in Prognosis of Nasopharyngeal Carcinoma.Frontiers in oncology · 2019Article
- Adjuvant chemotherapy improves prognosis of resectable stage IV colorectal cancer: a comparative study using inverse probability of treatment weighting.Therapeutic advances in medical oncology · 2019Article
- Immune inflammation indicators in anal cancer patients treated with concurrent chemoradiation: training and validation cohort with online calculator (ARC: Anal Cancer Response Classifier).Cancer management and research · 2019Article
- Article
- Intrahepatic cholangiocarcinoma prognostic determination using pre-operative serum C-reactive protein levels.BMC cancer · 2016Article
- Impact of inappropriate lymphadenectomy on lung metastasectomy for patients with metastatic colorectal cancer.Surgery today · 2016Observational
- Serum Ferritin as a Prognostic Biomarker for Survival in Relapsed or Refractory Metastatic Colorectal Cancer.Journal of Cancer · 2016Article
- Article
- Inflammation-based factors and prognosis in patients with colorectal cancer.World journal of gastrointestinal oncology · 2015Review
- Article
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Authors and funding
7 authors.
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Abstract
purposePrevious studies have revealed that an elevated preoperative serum C-reactive protein (CRP) level is associated with a poor prognosis in patients with various malignant tumors. The aim of this study was to determine the clinical significance of the preoperative serum CRP level in patients with stage IV colorectal cancer.
methodsWe enrolled 144 patients who underwent surgery for stage IV colorectal cancer. A total of 53 patients with a serum CRP level of ≥ 1.0 mg/dl were classified as the high CRP individuals. The association between the preoperative serum CRP level and survival was retrospectively assessed.
resultsThe cancer-specific survival of the patients with a high CRP level was significantly worse than that of the patients with a low CRP level. A multivariate analysis indicated that the curability (non-curative surgery), the number of organs with metastasis (more than one organ), the tumor diameter (≥ 5 cm), lymphatic involvement, histological differentiation (non-differentiated) and a high CRP level (≥ 1.0 mg/dl) were independent risk factors for a poor survival.
conclusionsA high preoperative serum CRP level is a convenient biomarker for identifying patients with a poor prognosis for stage IV colorectal cancer.
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