SynthesisEuropean radiology2014
Perforation rate in CT colonography: a systematic review of the literature and meta-analysis.
Synthesis in European radiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- PillCam COLON 2 for investigation of the colon through direct visualisation: systematic review and economic evaluation.Health technology assessment (Winchester, England) · 2026Pooled it
- Imaging alternatives to colonoscopy: CT colonography and colon capsule. European Society of Gastrointestinal Endoscopy (ESGE) and European Society of Gastrointestinal and Abdominal Radiology (ESGAR) Guideline - Update 2020.European radiology · 2021Guideline
- Clinical indications for computed tomographic colonography: European Society of Gastrointestinal Endoscopy (ESGE) and European Society of Gastrointestinal and Abdominal Radiology (ESGAR) Guideline.European radiology · 2015Guideline
- Contrast-enhanced CT colonography in colon cancer: expanding roles in staging, surgical planning and clinical decision-making.Abdominal radiology (New York) · 2026Review
- CT colonography for assessing visceral obesity: clinical utility beyond colorectal screening.Abdominal radiology (New York) · 2026Article
- The potential of CT colonography for colorectal cancer screening in Japan.Japanese journal of radiology · 2025Review
- CT colonography: revisited after 30 years.Insights into imaging · 2025Article
- Navigating the Second Victim Experience in Gastrointestinal Endoscopy and Colonoscopy.JGH open : an open access journal of gastroenterology and hepatology · 2025Article
- Diagnostic Yield of Combining CT Colonoscopy and Endoscopy to Investigate Colorectal Cancer.Journal of gastrointestinal cancer · 2025Article
- Cost-effectiveness of FIT and a FIT-based model to optimise symptomatic diagnosis of colorectal cancer: health economic modelling for the COLOFIT project.BMJ public health · 2025Article
- Caecal perforation from CT colonography: an unexpected complication.Journal of surgical case reports · 2023Article
- CT Colonography Is the Perfect Colorectal Screening Test That Unfortunately Few People Use Yet.Korean journal of radiology · 2023Article
- Is there need for routine CT colonography after CT-verified uncomplicated diverticulitis of the sigmoid colon?European journal of radiology open · 2021Article
- Cost-effectiveness analysis of alternative colorectal cancer screening strategies in high-risk individuals.Therapeutic advances in gastroenterology · 2021Article
- Cost-effectiveness analysis of alternative colon cancer screening strategies in the context of the French national screening program.Therapeutic advances in gastroenterology · 2020Article
- Computed tomography colonography: a new threat to the spleen?Annals of the Royal College of Surgeons of England · 2019Article
- [Colorectal cancer: role of imaging in screening].Der Radiologe · 2019Article
- Colon cancer screening with CT colonography: logistics, cost-effectiveness, efficiency and progress.The British journal of radiology · 2018Review
- Imaging the operated colon using water-enema multidetector CT, with emphasis on surgical anastomoses.Insights into imaging · 2018Review
- Review of radiological screening programmes for breast, lung and pancreatic malignancy.Quantitative imaging in medicine and surgery · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe primary aim was to assess the perforation rate of CTC; the secondary aim was to identify potential clinical/technical predictors of this complication.
methodsMethods for analysis were based on PRISMA (preferred reporting items for systematic reviews and meta-analyses). From the selected studies, the rate of CTC perforation and patient/technical characteristics potentially associated with this event were extracted. Forest plots showing individual and pooled estimates of the perforation rate were obtained for all analyses. I(2) was used to evaluate heterogeneity between studies.
resultsEleven articles out of the 187 initially identified were selected for the analysis (103,399 patients). There were 29,048 (28%) asymptomatic individuals and 30,773 (30%) symptomatic patients; this characteristic was not reported in the remaining subjects (42%). Colon distension was obtained manually in 69,222 (67%) and using an automated carbon dioxide insufflator in 26,479 (26%) patients; in the remaining 7% of patients, this information was missing. Twenty-eight colonic perforations were reported, with the CTC perforation rate estimated to be 0.04% (95% CI. 0.00-0.10), 19-fold higher in symptomatic than in screening subjects (OR: 19.2, CI 3.3-108 and P = 0.001). The surgical rate was 0.008%. No CTC-related deaths were reported.
conclusionsThe perforation rate in CTC is very low, particularly considering asymptomatic individuals. KEY POINTS: • This is the first meta-analysis on this topic, based on 100,000 patients. • The CTC-related colorectal perforation rate is 0.04%, 0.02% in asymptomatic subjects. • The CTC-induced surgery rate is 0.008% (1:12,500). • The perforation rate in CTC is low, particularly in average-risk, asymptomatic individuals.
Indexed as
Identifiers
24816935What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.