ArticlePloS one2014
IncA/C plasmid-mediated spread of CMY-2 in multidrug-resistant Escherichia coli from food animals in China.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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30 citing papers in PubMed, 58 citations in OpenAlex.
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- Characterisation and mobilisation of IncA/C plasmid-mediated antibiotic resistance in Edwardsiella ictaluri.Journal of global antimicrobial resistance · 2023Article
- Evaluating Antimicrobial Resistance Trends in CommensalMicroorganisms · 2023Article
- Comparative genetic characterization of CMY-2-type beta-lactamase producing pathogenic Escherichia coli isolated from humans and pigs suffering from diarrhea in Korea.Annals of clinical microbiology and antimicrobials · 2023Article
- Emergence and Spread of Cephalosporinases in Wildlife: A Review.Animals : an open access journal from MDPI · 2021Review
- Genetic Characterization of AmpC and Extended-Spectrum Beta-Lactamase Phenotypes inFrontiers in cellular and infection microbiology · 2021Article
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- Comparative Genomic Analysis of Third-Generation-Cephalosporin-Resistant Escherichia coli Harboring theAntimicrobial agents and chemotherapy · 2020Article
- Characterization of IncC Plasmids in Enterobacterales of Food-Producing Animals Originating From China.Frontiers in microbiology · 2020Article
- Molecular Characterization of Fecal Extended-Spectrum β-Lactamase- and AmpC β-Lactamase-ProducingFrontiers in microbiology · 2020Article
- Metal impacts on the persistence and proliferation of β-lactam resistance genes in Xiangjiang River, China.Environmental science and pollution research international · 2019Article
- Characterization of CMY-2-type beta-lactamase-producing Escherichia coli isolated from chicken carcasses and human infection in a city of South Brazil.BMC microbiology · 2019Article
- Dissemination of Multidrug-Resistant CommensalFrontiers in microbiology · 2019Article
- Molecular and Phenotypic Characteristics ofBioMed research international · 2019Article
- Antimicrobial Resistance inMicrobiology spectrum · 2018Review
- Detection of CTX-M-15 harboring Escherichia coli isolated from wild birds in Tunisia.BMC microbiology · 2018Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo obtain a broad molecular epidemiological characterization of plasmid-mediated AmpC β-lactamase CMY-2 in Escherichia coli isolates from food animals in China.
methodsA total of 1083 E. coli isolates from feces, viscera, blood, drinking water, and sub-surface soil were examined for the presence of CMY-2 β-lactamases. CMY-2-producing isolates were characterized as follows: the blaCMY-2 genotype was determined using PCR and sequencing, characterization of the blaCMY-2 genetic environment, plasmid sizing using S1 nuclease pulsed-field gel electrophoresis (PFGE), PCR-based replicon typing, phylogenetic grouping, XbaI-PFGE, and multi-locus sequence typing (MLST).
resultsAll 31 CMY-2 producers were only detected in feces, and presented with multidrug resistant phenotypes. All CMY-2 strains also co-harbored genes conferring resistance to other antimicrobials, including extended spectrum β-lactamases genes (blaCTX-M-14 or blaCTX-M-55), plasmid-mediated quinolone resistance determinants (qnr, oqxA, and aac-(6')-Ib-cr), floR and rmtB. The co-transferring of blaCMY-2 with qnrS1 and floR (alone and together) was mainly driven by the Inc A/C type plasmid, with sizes of 160 or 200 kb. Gene cassette arrays inserted in the class 1 or class 2 integron were amplified among 12 CMY-2 producers. CMY-2 producers belonged to avirulent groups B1 (n = 12) and A (n = 11), and virulent group D (n = 8). There was a good correlation between phylogenetic groups and sequence types (ST). Twenty-four STs were identified, of which the ST complexes (STC) 101/B1 (n = 6), STC10/A (n = 5), and STC155/B1 (n = 3) were dominant.
conclusionsCMY-2 is the dominant AmpC β-lactamase in food animals and is associated with a transferable replicon IncA/C plasmid in the STC101, STC10, and STC155 strains.
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